• Hadeer A Aglan Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Giza, Egypt.
  • Mostafa Mabrouk Refractories, Ceramics and Building Materials Department, National Research Centre, Giza, Egypt.
  • Riham M Aly Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Giza, Egypt.
  • Hanan H Beherei Refractories, Ceramics and Building Materials Department, National Research Centre, Giza, Egypt.
  • Hanaa H Ahmed Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Giza, Egypt.




Mesenchymal stem cells, Cerium oxide nanoparticles, Yttrium oxide nanoparticles, Antioxidant effect, Proliferative impact


Objective: This work was designed to explore if cerium oxide (CeO2) and yttrium oxide (Y2O3) nanoparticles as antioxidant agents could potentiate the proliferation of mesenchymal stem cells (MSCs) derived from human dental pulp (hDPSCs).

Methods: Nanoparticles were characterized by transmission electron microscopy, particle size and zeta potential, X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscope (SEM) along with energy-dispersive X-ray spectrometry. Furthermore, MSCs were isolated from human dental pulp, propagated and characterized by flow cytometry. Thereafter, the proliferative impact of the suggested nanoparticles on hDPSCs was investigated by 3-(4,5)-dimethylthiazol)-2,5-diphenyl tetrazolium bromide assay.

Results: Different sizes (14.09–26.50 nm and 18.80–31.31 nm) for CeO2 and Y2O3 respectively, morphology, charges, and proliferative efficacy in hDPSCs were recorded for both nanoparticles.

Conclusion: Generally speaking, the tested nanoparticles heightened the proliferative response of hDPSCs with the most prominent effect exerted by 15 μg/ml of CeO2 and 5 μg/ml of Y2O3. It is reasonable to assume that the antioxidant property of CeO2 and Y2O3 be involved in strengthening the proliferation process of hDPSCs.


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How to Cite

Aglan, H. A., M. Mabrouk, R. M. Aly, H. H. Beherei, and H. H. Ahmed. “HARNESSING THE ANTIOXIDANT PROPERTY OF CERIUM AND YTTRIUM OXIDE NANOPARTICLES TO ENHANCE MESENCHYMAL STEM CELL PROLIFERATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 9, Sept. 2018, pp. 436-42, doi:10.22159/ajpcr.2018.v11i9.27914.



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