CLINICAL SIGNIFICANCE OF PROCALCITONIN AND C-REACTIVE PROTEIN IN THE PREDICTION OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS


Hanaa H. Ahmed, Wafaa Gh Shousha, Hatem A El Mezayen, Ibrahim A Emara, Marwa E Hassan

Abstract


 

 Objective: This work was delineated to assess procalcitonin (PCT) and C-reactive protein (CRP) as prognostic markers for cardiovascular complication in type 2 diabetic patients.

Methods: Forty diabetic patients without cardiovascular disease (CVD), 40 diabetic patients with CVD, and 20 healthy control counterparts were participated in this study. Serum PCT and CRP levels were assayed and correlated with metabolic parameters. Receiver operating characteristic (ROC) curve analysis was done for each biochemical marker.

Results: The mean level of PCT was 707.17±99.19 ng/l in diabetic patients versus 881.30±123.56 ng/l for the cardio-diabetic patients (p<0.0001). The mean value of CRP was 34.43±17.27 mg/l in diabetic patients versus 50.32±20.19 mg/l for the cardio-diabetic patients (p=0.0003). PCT levels were significantly amplified in the cardio-diabetic patients with increasing CRP, triglycerides (TG), fasting blood glucose (FBG), and cholesterol (p=0.004, 0.0005, 0.002, and 0.01, respectively). CRP levels were significantly enhanced in the cardio-diabetic patients with increasing TG, FBG, cholesterol, and microalbumin (p=0.002, 0.047, 0.003, and 0.001 respectively). ROC curve analysis for PCT and CRP revealed that the area under curve (AUC) was 0.878 and 0.727, respectively. These findings indicate the good validity of the above biomarkers especially PCT as a prognostic marker for cardiovascular complication in type 2 diabetic patients.

Conclusion: This study evidences the usefulness of measuring serum levels of PCT and CRP in diagnosis of cardiovascular complication in type 2 diabetic patients.


Keywords


Procalcitonin, Diabetes mellitus, C-reactive protein, Cardiovascular complications.

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About this article

Title

CLINICAL SIGNIFICANCE OF PROCALCITONIN AND C-REACTIVE PROTEIN IN THE PREDICTION OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Keywords

Procalcitonin, Diabetes mellitus, C-reactive protein, Cardiovascular complications.

DOI

10.22159/ajpcr.2017.v10i9.19524

Date

01-09-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 297-306

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Hanaa H. Ahmed
Department of Hormones, National Research Centre, Giza, Egypt.
Egypt

Wafaa Gh Shousha
Department of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Egypt

Hatem A El Mezayen
Department of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Egypt

Ibrahim A Emara
Department of Biochemistry, National Institute of Diabetes and Endocrinology, Cairo, Egypt
Egypt

Marwa E Hassan
Department of Biochemistry, National Institute of Diabetes and Endocrinology, Cairo, Egypt
Egypt


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