CARBAMAZEPINE-INDUCED TOXIC EPIDERMAL NECROLYSIS: A CASE REPORT

Sherin Alexander; Devayani Santhu; Narendran T; Julie Mariam Joshua; Meenu Vijayan; Jacob Thomas

doi:10.22159/ajpcr.2018.v11i12.28294

Authors

Sherin Alexander Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.
Devayani Santhu Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.
Narendran T Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.
Julie Mariam Joshua Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.
Meenu Vijayan Department of Dermatology, Amrita Institute of Medical Sciences, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.
Jacob Thomas Department of Dermatology, Amrita Institute of Medical Sciences, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i12.28294

Keywords:

Toxic epidermal necrolysis, Carbamazepine, Erythematous lesion

Abstract

Toxic epidermal necrolysis (TEN) is a life-threatening dermatological disorder characterized by erythematous lesions, necrosis, exfoliation, sepsis, and death. This may be due to different reasons such as chemical exposure, systemic infections, or some reactions of drugs such as carbamazepine, phenytoin, allopurinol, lamotrigine, and nonsteroidal anti-inflammatory drugs. In this case, the patient was on carbamazepine for the management of alcohol withdrawal symptoms. Moreover, this might be the reason for the occurrence of TEN. For his condition, he had given corticosteroids, antibiotics for sepsis, and other supportive measures.

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Author Biography

Sherin Alexander, Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Kerala, India.

Assistant Professor, Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham

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