INCIDENTAL DETECTION OF CARCINOMA IN SITU IN FIBROADENOMA OF BREAST IN A YOUNG WOMAN: A RARE FINDING

  • Nikitha Valerina Kairanna Department of Pathology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India http://orcid.org/0000-0003-3326-1859
  • Brijmohan Kumar Singh Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
  • Pavithra P Department of Pathology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

Abstract

Fibroadenoma is the most common benign tumor of the breast in young females. Breast cancer arising within a fibroadenoma is a rare phenomenon. The incidence of carcinoma within a fibroadenoma is reported to be between 0.1% and 0.3% in a screened population, with a peak age of occurrence between the 4th and 5th decade. We present a case of 29-year-old female with ductal carcinoma in situ in a background of fibroadenoma. There is a low percentage of fibroadenomas harboring carcinoma; however, all breast lumps should be seriously managed; extirpation and histological examination is recommended.

Keywords: Fibroadenoma, Carcinoma in situ, Benign tumor.

Author Biography

Nikitha Valerina Kairanna, Department of Pathology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
Associate Professor, Department of Pathology

References

1. Kujiper A, Mommers EC, Van der Wall E, Van Diest PJ. Histopathology of the fibroadenomas of the breast. Pathol 2001;115:736.
2. Abu-Rahmeh Z, Nseir W, Naroditzky I. Invasive ductal carcinoma within fibroadenoma and lung metastases. Int J Gen Med 2012;5:19-21.
3. Nayak R. Medullary breast carcinoma in a young female aged 30: A rare case report. Int J Pharm Bio Sci 2014;5(3):461-4.
4. Reddy KC, Kumar KM, Divyagna T. Incidentally detected carcinoma in situ in a fibroadenoma breast in a postmenopausal woman: A case report. Int Arch Integr Med 2015;2:197-202.
5. Cheatle GL, Cutler M. Tumours of the Breast. Their pathology, Symptoms, Diagnosis and Treatment. London: Edward Arnoled and Co.; 1931. p. 483.
6. Shah AK, Pathak R, Banerje Niazi M, Girishkumar HT. Lobular carcinoma-in-situ within a fibroadenoma of the breast. Postgrad Med J 1999;75:293-4.
7. Rao S, Latha PS, Ravi A, Thanka J. Ductal carcinoma in multiple fibroadenoma: Diagnostic inaccuracies. J Cancer Res Ther 2010;6:385-7.
8. Tiu CM, Chou YH, Chiou SY, Hsu CY, Chen SP, Chiang HR, et al. Development of a carcinoma in situ in a fibroadenoma. J Ultrasound Med 2006;25:1335-8.
9. Diaz NM, Palmer JO, Mc Divett RW. Carcinoma arising within fibroadenomas of the breast; A clinic pathologic study of 105 patients. Am J Clin Pathol 1991;95:614-22.
10. Ozzello L, Gump FE. The management of patients with carcinomas in fibroadenomatous tumours of the breast. Surg Gynecol Obstet 1985;160:9-104.
11. Fondo EY, Rosen PP, Frachia AA, Urban JA. The problem of carcinoma developing in a fibroadenoma. Cancer 1979;43:450-6.
12. Gashi-Luci LH, Limani RA, Kurshumliu FI. Invasive ductal carcinoma within fibroadenoma: A case report. Cases J 2009;2:174.
13. Limite G, Esposito E, Sollazzo V, Ciancia G, Formisano C, Di Micco R, et al. Lobular intraepithelial within breast fibroadenoma. BMC Res Notes 2013;6:267.
14. Kujiper A, Preisler-Adams SS, Rahusen FD, Gille JJ, Wall E, van Diest PJ. Multiple fibroadenomas harboring carcinoma in situ in a woman with a family history of breast/ovarian cancer. J Clin Pathol 2002;55:795-7.
15. Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD Jr., Rados MS, et al. Long term risk of breast cancer in women with fibroadenoma. N Engl J Med 1994;331:10-5.
16. Abe H, Hanasawa K, Naitoh H, Endo Y, Tani T, Kushima R. Invasive ductal carcinoma within a fibroadenoma of the breast. Int J Clin Oncol 2004;9:334-8.
17. Stafyla V, Kotsifopoulos N, Grigoriades K, Kassaras G, Sakorafas GH. Lobular carcinoma in situ of the breast within a fibroadenoma. A case report. Gynecol Oncol 2004;94:572-4.
18. Kurosumi M, Itokazy R, Mamiya Y, Kishi K, Takayama SH, Nagasawa M, et al. Invasive ductal carcinoma with a predominant intraductal component arising in a fibroadenoma of the breast. Pathol Int 1994;44:874-7.
19. Azzopardi JG, Ahmed A, Mills RR. Problems in breast pathology. In: Bennigton JC, editor. Major Problems in Pathology. Edinburgh: WB Saunders Company Ltd.; 1979. p. 325-8.
20. Kwon MJ, Park HR, Seo J, Kim DH, Jung K, Lim YA, et al. Simultaneous occurrence of ductal carcinoma in situ within juvenile fibroadenoma in both breasts: A brief case report. Korean J Pathol 2014;48:164-6.
21. Preethi MI, Kumar PS, Karthikeyan S, Namboori PK. ‘BRCA1’ responsiveness towards breast cancer-a population-wise pharmacogenomic analysis. Int J Pharm Pharm Sci 2016;8:267-70.
Statistics
348 Views | 276 Downloads
Citatons
How to Cite
Valerina Kairanna, N., B. Kumar Singh, and P. P. “INCIDENTAL DETECTION OF CARCINOMA IN SITU IN FIBROADENOMA OF BREAST IN A YOUNG WOMAN: A RARE FINDING”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 1-3, doi:10.22159/ajpcr.2019.v12i1.28326.
Section
Case Study(s)