ANTI-METALOTOXIC PROPERTIES OF KELAKAI (STENOCHLAENA PALUSTRIS) LEAVES EXTRACT AGAINST CADMIUM-INDUCED LIVER TISSUE DAMAGE


Agung Biworo, Nurul Ainun Azizi, Rizki Padelia, Muhammad Andino Raharja, Ozanata Azima, Eko Suhartono

Abstract


Objective: The present study was undertaken to investigate the anti-metalotoxic activity of the leaves extract of Stenochlaena palustris (kelakai; S. palsutris) on cadmium (Cd)-induced liver tissue damage.

Methods: Liver tissue damage was induced by the administration of cadmium sulfate (CdSO4) at a dose 3 mg/l. Anti-metalotoxic effect of the extracts was determined by assessing the concentration of malondialdehyde (MDA), carbonyl compound (CC), conjugated dienes (CD), and advanced oxidation protein products (AOPPs) induced by Cd with and without the presence of the extract.

Results: The results of this present studies showed that treatment with CdSO4 significantly increase the levels of MDA, CC, CD, and AOPPs. The leaves extract of S. palustris significantly decrease the levels of all measured parameter in liver tissue.

Conclusion: The present study demonstrated that Cd could induced the liver tissue damage, and the extract of S. palsutris showed the anti-metalotoxic activity to reduce the damage.


Keywords


Cadmium, Liver, Oxidative Stress, Stenochlaena palustris.

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About this article

Title

ANTI-METALOTOXIC PROPERTIES OF KELAKAI (STENOCHLAENA PALUSTRIS) LEAVES EXTRACT AGAINST CADMIUM-INDUCED LIVER TISSUE DAMAGE

Keywords

Cadmium, Liver, Oxidative Stress, Stenochlaena palustris.

DOI

10.22159/ajpcr.2018.v11s3.30028

Date

06-10-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Special issue 3 2018 Page: 43-46

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Agung Biworo
Department of Pharmacology, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Indonesia

Nurul Ainun Azizi
Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Indonesia

Rizki Padelia
Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Indonesia

Muhammad Andino Raharja
Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Indonesia

Ozanata Azima
Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Indonesia

Eko Suhartono
Department of Medical Chemistry/ Biochemistry, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Indonesia


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