COUMARINS: A UNIQUE SCAFFOLD WITH VERSATILE BIOLOGICAL BEHAVIOR

  • MANDEEP KUMAR GUPTA Moradabad Educational Trust Group of Institutions, Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
  • SUSHIL KUMAR Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India.
  • SACHIN CHAUDHARY Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

Abstract

Benzopyrones are the club of compounds that can be coumarins or flavonoids. The hydroxyl derivatives of coumarins such as 4-hydroxycoumarins and 7-hydroxycoumarins have extensive biological activities which have employed for the synthesis of miscellaneous coumarin derivatives. These derivatives have exhibited impressive pharmacological and physiological activities such as anticoagulant, antibacterial, antiviral, antitumor, bactericidal, fungicidal, anti-inflammatory agents, and anti-HIV activity. This review comprised pharmacokinetic studies, including absorption, distribution, and metabolism of coumarin analogs along with toxicological studies. The studies of coumarins and their derivatives exhibiting immense pharmacological activity are also summarized in the current study.

Keywords: Benzopyrones, Coumarins, Anticoagulant, Antibacterial, Antiviral, Antitumor.

Author Biographies

MANDEEP KUMAR GUPTA, Moradabad Educational Trust Group of Institutions, Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.

Assistant Professor

SACHIN CHAUDHARY, Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

Director, School of Pharmaceutical Sciences, IFTM University, Moradabad-244001, Uttar Pradesh, India.

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GUPTA, M. K., S. KUMAR, and S. CHAUDHARY. “COUMARINS: A UNIQUE SCAFFOLD WITH VERSATILE BIOLOGICAL BEHAVIOR”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 3, Feb. 2019, pp. 27-38, https://innovareacademics.in/journals/index.php/ajpcr/article/view/30635.
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