SYNTHESIS AND INVESTIGATION OF ANTHELMINTIC, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 3,3-DIPHENYL PROPANAMIDE DERIVATIVES

  • Sachin Chaudhary Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
  • Harish Chandra Verma Moradabd Education Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
  • Mandeep Kumar Gupta Moradabd Education Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
  • Ramesh Kumar Gupta Moradabd Education Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
  • Amit Kumar Neelkanth Group of Institutions, College of Pharmacy, Meerut, Uttar Pradesh, India.
  • Abdel Nasser El-shorbagi Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

Abstract

Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.

Methods: All the compounds were characterized by infrared (IR) and1H- nuclear magnetic resonance spectrometry data. The synthesized derivatives were investigated for their anthelmintic activity employing housefly worms method and earthworm species model. The antibacterial and antifungal activity was performed employing cup plate method.

Results: The synthesized compounds (VII and VIII) exhibited maximum anthelmintic activity as compared with standard drug albendazole at doses of 50 and 100 mg/mL, due to minimal paralyzing and death time in both housefly and earthworm models. The compounds (IV, VII, and VIII) at 50 μg/mL exhibited maximum activity against Gram-negative bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa as compared with ciprofloxacin and same compounds exhibited maximum antifungal activity against Candida albicans and Aspergillus niger in comparison with standard drug griseofulvin at 50 μg/mL.

Conclusion: The synthesized compounds bearing amino acid moiety in their structure (VII-VIII) exhibited impressive anthelmintic activity in comparison with albendazole. This suggests that amino acid/peptide derivative of diphenyl propanamides can act as great anthelmintic agents. Further, the research can be performed to design potent antimicrobial diphenyl propanamide derivatives.

 

Keywords: 3, 3-Diphenyl propanamide, Antibacterial, Antifungal, Anthelmintic.

Author Biographies

Sachin Chaudhary, Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Department of Medicinal Chemistry, Lecturer
Harish Chandra Verma, Moradabd Education Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
Asst Professor
Mandeep Kumar Gupta, Moradabd Education Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
Asst Professor
Ramesh Kumar Gupta, Moradabd Education Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
Asst Professor
Amit Kumar, Neelkanth Group of Institutions, College of Pharmacy, Meerut, Uttar Pradesh, India.
Principal
Abdel Nasser El-shorbagi, Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Professor

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Chaudhary, S., H. C. Verma, M. K. Gupta, R. K. Gupta, A. Kumar, and A. N. El-shorbagi. “SYNTHESIS AND INVESTIGATION OF ANTHELMINTIC, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 3,3-DIPHENYL PROPANAMIDE DERIVATIVES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 310-5, doi:10.22159/ajpcr.2019.v12i1.30094.
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