FORMULATION AND STABILITY EVALUATION OF ATENOLOL GEL IN TWO DIFFERENT BASES
Objective: The aim of the research about atenolol gel is to formulate and evaluate its stability in hydroxypropyl methylcellulose (HPMC) and Aqupec HV-505 gel base.
Methods: Gels were formulated using Acupev HV-505 and HPMC at three different concentrations. Physicochemical evaluation and stability testing were performed including organoleptic examination, pH, viscosity, consistency, bleeding, qualitative analysis by thin-layer chromatography (TLC), and quantitative analysis by UV-visible spectrophotometry during 56 days of storage.
Results: Physicochemical evaluation showed that the best formula was the one with 1% Aqupec HV-505 base (FA2). Further investigation was conducted by varying atenolol concentration to study the influence on gel stability. Evaluation on organoleptic performance, pH, viscosity, consistency, bleeding, microbiology, and qualitative and quantitative stability testing using TLC and UV-visible Spectrophotometry during 56 days of storage showed that the best gel formula was FA22, the one using 1% Aqupec HV-505 with 0.5% Atenolol The patch test showed that all atenolol gels were safe to be used.
Conclusions: About 1% Aqupec HV-505 provided good physical properties and physicochemical stability to be used as gel base.
2. Mohammed A, et al. Transdermal Delivery of ?-blockers; 2006. Available from: http://www.ingentaconnect.com.
3. Bhaskaran N, Harsha SN. Effect of permeation enhancer and iontophoresis on permeation of atenolol from transdermal gels. 2000;62:424-6.
4. Shinde UA, Modani SH, Singh KH. Design and development of repaglinide microemulsion gel for transdermal delivery. AAPS PharmSciTech 2018;19:315-25.
5. Lionberger DR, Brennan MJ. Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: Diclofenac epolamine topical patch. J Pain Res 2010;3:223-33.
6. Deveda P, Jian N, Khambete H, Jain S. Gellified emulsion for sustain delivery of itraconazole for topical fungal diseases. Int J Pharm Pharm Sci 2010;2:10.
7. El Laithy HM, El-Shaboury KM. The development of cutina lipogels and gel microemulsion for topical administration of fluconazole. AAPS PharmSciTech 2002;3:E35.
8. Kumar L, Verma R. In vitro evaluation of topical gel prepared using natural polymer. Int J Drug Deliv 2010;2:58-63.
9. Gennaro AR, editor. Remington: The Science and Practice of Pharmacy. 19th ed. Easton: Mack Publishing Company; 1995.
10. Ansel HC, Allen LV Jr., Popovich NG. Pharmaceutical Dosage forms and Drug Delivery Systems. 7th ed. New York: Lippincott Williams and Wilkins; 1999.
11. Aparna C, Srinivas KS, Patnaik R. Enhanced transdermal permeability of telmisartan by a novel nanoemulsion gel. Int J Pharm Pharm Sci 2015;7:335-42.
12. Kim J, Shin SC. Controlled release of atenolol from the ethylene-vinyl acetate matrix. Int J Pharm 2004;273:23-7.
13. Cho CW, Shin SC. Enhanced transdermal delivery of atenolol from the ethylene-vinyl acetate matrix. Int J Pharm 2004;287:67-71.
14. Gupta SP, Jain SK. Development of matrix-membrane transdermal drug delivery system for atenolol. Drug Deliv 2004;11:281-6.
15. Acharya A, Kumar GB, Ahmed MG, Paudel S. A novel approach to increase the bioavailability of candesartan cilexetil by proniosomal gel formulation: In-vitro and in-vivo evaluation. Int J Pharm Pharm Sci 2016;8:413-20.
16. Souza C, de Freitas LAP, Maia Campos PMBG. Topical formulation containing beeswax-based nanoparticles improved in vivo skin barrier function. AAPS PharmSciTech 2017;18:2505-16.
17. Wagemaker TA, Silva SA, Leonardi GR. Maia campos PMBG green Coffea arabica L. seed oil influences the stability and protective effects of topical formulations. Ind Crop Prod 2015;63:34-40.
18. Tadros T. Application of rheology for assessment and prediction of the long-term physical stability of emulsions. Adv Colloid Interface Sci 2004;108-109:227-58.
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