A STUDY ON ANTHELMINTIC AND ANTIBACTERIAL EFFECTS OF EXTRACTS FROM CHINESE HONEYSUCKLE (QUISQUALIS INDICA L) SEEDS AND ARECA (ARECA CATECHU) NUTS

Anthelmintic and antibacterial effects of Chinese honeysuckle seeds and Areca nuts

  • NGUYENTHANH HAI Department of Plant Biotechnology, Faculty of Biotechnology, Vietnam National University of Agriculture, Gia Lam, Hanoi, Vietnam.
  • MIYAMOTO ATSUSHI Department of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
  • HA THI THANH NGUYEN Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Gia Lam, Hanoi, Vietnam.
  • THANH VAN NGUYEN Department of Animal Surgery and Reproduction, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Gia Lam, Hanoi, Vietnam.

Abstract

Objectives: This study aimed to investigate the anthelmintic and antibacterial effects of Chinese honeysuckle (Quisqualis indica L) seeds and Areca (Areca catechu) nuts, to verify their potentials of applying in practice.


Materials and Methods: Aqueous extracts of plants at different concentrations were used to test with porcine ascarids, porcine flukes, and Escherichia coli (E. coli) strains isolated from pigs. The time that caused the death of 50% and 100% experimental endoparasites (LD50 and LD100) was used to verify the anthelmintic effects. Diameters of the inhibitory zone induced by extracts investigated with cylinder agar diffusion method were measured to assess their antibacterial effects.


Results and Discussion: Both of Chinese honeysuckle seeds and areca nuts showed anthelmintic and antibacterial effects when tested against ascarides, flukes, and E. coli strains. These effects were all exerted in dose-dependent manners. Chinese honeysuckle seed extracts had stronger effects on ascarides, as shown by their significantly shorter LD50 and LD100 time. On the other hand, areca nut extracts were more effective against flukes and bacteria, which was evident by the significantly shorter lethal time values and significantly wider inhibitory zone diameters.


Conclusion: This study demonstrated the anthelmintic and antibacterial effects of Chinese honeysuckle seeds and areca nuts, and therefore partly gives pharmacological basis to explain their traditional use in Vietnamese folk medicine. While Chinese honeysuckle seeds had more potential on ascarids, areca nuts were superior in effects against flukes and bacteria. However, future research that involved in vivo experiments is still required to further assess the applicability of these two promissory plants.

Keywords: Chinese honeysuckle seed,, Areca nut,, Aqueous extract,, Anthelmintic effect,, Antibacterial effect,, Endoparasite, Bacteria.

Author Biographies

MIYAMOTO ATSUSHI, Department of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.

PhD, DVM

HA THI THANH NGUYEN, Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Gia Lam, Hanoi, Vietnam.

PhD, DVM

THANH VAN NGUYEN, Department of Animal Surgery and Reproduction, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Gia Lam, Hanoi, Vietnam.

PhD, DVM, University lecturer

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NGUYENTHANH HAI, MIYAMOTO ATSUSHI, HA THI THANH NGUYEN, and THANH VAN NGUYEN. “A STUDY ON ANTHELMINTIC AND ANTIBACTERIAL EFFECTS OF EXTRACTS FROM CHINESE HONEYSUCKLE (QUISQUALIS INDICA L) SEEDS AND ARECA (ARECA CATECHU) NUTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 6, Apr. 2019, pp. 88-92, https://innovareacademics.in/journals/index.php/ajpcr/article/view/32664.
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