HELICHRYSUM PETIOLARE HILLIARD AND B. L. BURTT: A REVIEW OF ITS MEDICINAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES
ETHNOPHARMACOLOGY OF HELICHRYSUM PETIOLARE
Keywords:Asteraceae,, Helichrysum petiolare,, Ethnopharmacology,, Herbal medicine,, Southern Africa
Helichrysum petiolare is a valuable and well-known medicinal herb in South Africa. A comprehensive review of phytochemical, medicinal uses, and biological activities of H. petiolare is presented in this study. Information on biological activities, medicinal uses, and phytochemistry of H. petiolare was gathered from several internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, PubMed, SciFinder, and BMC. Additional information on these aspects was sourced from pre-electronic sources such as journal articles, scientific reports, theses, books, and book chapters obtained from the University library. The current study revealed that H. petiolare is mainly used as herbal medicine for respiratory infections, diabetes, fever, headache, heart problem, high blood pressure, pain, reproductive problems, and wounds. Phytochemical studies showed that H. petiolare extracts and compounds isolated from the species have antifungal, anti-inflammatory, antibacterial, antioxidant, antityrosinase, antigenotoxicity, and cytotoxicity activities. This research showed that H. petiolare is an integral part of indigenous pharmacopeia in South Africa, but there is the lack of alignment between the known medicinal applications, phytochemistry, and biological activities of the species. Therefore, future research should focus on evaluating the chemical and pharmacological properties of H. petiolare extracts and compounds associated with the species.
Hilliard OM. Compositae in Natal. Pietermaritzburg: University of Natal Press; 1977.
Hilliard OM. Gnaphaliinae. In: Leistner OA, editor. Flora of Southern Africa: Asteraceae. Pretoria: National Botanical Institute; 1983. p. 1-325.
Fabian A, Germishuizen G. Wild Flowers of Northern South Africa. Vlaeburg: Fernwood Press; 1997.
Goldblatt P, Manning JC. Cape Plants: A Conspectus of the Cape Flora of South Africa. Cape Town: Strelitzia 9, National Botanical Institute; 2000.
Germishuizen G, Meyer NL. Plants of Southern Africa: An Annotated Checklist. Pretoria: Strelitzia 14, National Botanical Institute; 2003.
Vlok J, Schutte-Vlok AL. Plants of the Klein Karoo. Pretoria: Umdaus Press; 2010.
Eliovson S. South African Wild Flowers for the Garden: Bulbs, Annuals, Perennials, Succulents, Shrubs and Trees: How to Grow them, Identify them and Use them for Effect. Johannesburg: Howard Timmins; 1984.
Dyson A. Getting to know Kirstenbosch National Botanical Garden: Indigenous Healing Plants of the Herb and Fragrance Garden. Cape Town: National Botanical Institute; 1994.
Nowick E. Historical Common Names of Great Plains Plants, with Scientific Names Index. Lincoln: Zea Books; 2015.
Gulumian M, Yahaya ES, Steenkamp V. African herbal remedies with antioxidant activity: A potential resource base for wound treatment. Evid Based Complement Altern Med 2018;2018:58.
Oliver R. Helichrysum petiolare Hilliard and B. L. Burtt; 2019. Available from: http://www.pza.sanbi.org/helichrysum-petiolare. [Last accessed on 2019 Mar 15].
Randall JM. Weed Alert! New Invasive Weeds in California. California: Symposium Proceedings of the California Exotic Pest Plant Council; 1997. p. 1-6.
Di Tomaso J. In: Brunel S, editor. Don’t Plant a Pest Initiative. Mèze: Proceedings of the International Workshop Invasive Plants in Mediterranean Type Regions of the World; 2005. p. 118-22.
Thuiller W, Richardson DM, Pysek P, Midgley GF, Hughes GO, Rouget M. Niche-based modelling as a tool for predicting the risk of alien plant invasions at a global scale. Glob Change Biol 2005;11:2234-50.
Thomac C. Gardeners’ World Magazine: 101 Ideas for Pots: Fool Proofrecipes for Rear-Round Colour. Wemding: BBC Books; 2007.
Ogden S, Ogden LS. Plant-Driven Design: Creating Gardens that Honorplants, Place, and Spirit. London: Timber Press; 2008.
Van Jaarsveld E. Waterwise Gardening in South Africa and Namibia. Cape Town: Struik Lifestyle; 2010.
Welsh P. Pat Welsh’s Southern California Organic Gardening. San Francisco: Chronicle Books; 2010.
Caser M, Ruffoni B, Scariot V. Screening for drought tolerance in Salvia spp. and Helichrysum petiolare: A way to select low maintenance ornamental plants. Acta Hortic 2012;953:239-46.
Delivering Alien Invasive Species Inventories for European (DAISIE); 2019. Available from: http://www.europe-aliens.org. [Last accessed on 2019 Mar 11].
Hendy J. 30-Minute Gardening: Creative Solutions, Tips and Tricks for a Great Garden Super-Fast! London: Dorling Kindersley Ltd.; 2012.
Randall RP. A Global Compendium of Weeds. Western Australia: Department of Agriculture and Food; 2012.
Mouriño J, Fagúndez J, Bernárdez G. Distribution and Invasiveness of the Alien Plant Helichrysum petiolare Hilliard, BL Burtt (Asteraceae) in Northwest Iberian Peninsula. Pontevedra: NEOBIOTA 7th European Conference on Biological Invasions, September 2012; 2012.
Boyce RL. Invasive shrubs and forest tree regeneration. J Sustain For 2009;28:152-217.
Anderberg AA. Taxonomy and phylogeny of the tribe gnaphalieae (asteraceae). Opera Bot 1991;104:1-195.
Hickman JC. The Jepson Manual: Higher Plants of California. Berkeley: University of California Press; 1993.
Webb CJ, Sykes WR, Garnock-Jones PJ, Brownsey PJ. Checklist of dicotyledons, gymnosperms, and pteridophytes naturalised or casual in New Zealand: Additional records 1988-1993. New Zealand J Bot 1995;33:151-82.
Anderson LW, Di Tomaso L, Howald A, Randall J, Rejmanek M, Chairman JS. Exotic Pest Plants of Greatest Ecological Concern in California. California: California Exotic Plant Pest Council Special Publication; 1996.
Zimmermann HG, Klein H. The use of biological control agents for the control of plant invaders and the importance of partnerships. In: Preston G, Brown G, Van Wyk E, editors. Proceedings of the Best Management Practices Symposium. Cape Town: The Working for Water Program; 2000. p. 130-8.
Prunera-Olivé J, Galbany-Casals M, Cremades J, Fagúndez J. A new hybrid between two alien Helichrysum species (compositae, gnaphalieae) from NW Spain. Biol Invasions 2019;21:1481-90.
de Almeida JD, Freitas H. Exotic naturalized flora of continental Portugal: A reassessment. Bot Complut 2006;30:117-30.
Howell JT. Marin Flora: Manual of the Vascular Plants and Ferns of Marin County, California. Berkeley: University of California Press; 1970.
Smith GL, Wheeler CR. A Flora of the Vascular Plants of Mendocino County. San Francisco: University of San Francisco; 1992.
Van Wyk BE, Oudtshoorn BV, Gericke N. Medicinal Plants of South Africa. Pretoria: Briza Publications; 2013.
Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Edinburgh: E and S Livingstone; 1962.
Hutchings A, Johnson CT. Glimpses of a xhosa herbal. Veld Flora 1986;72:59-62.
Mabogo DE. The Ethnobotany of the Vhavenda. MSc Dissertation. Pretoria: University of Pretoria; 1990.
Pujol J. NaturAfrica: The Herbalist Handbook, African Flora, Medicinal Plants. Durban: Jean Pujol Natural Healers Foundation; 1990.
Roberts M. Indigenous Healing Plants. Johannesburg: Southern Book Publishers; 1990.
Hutchings A, van Staden J. Plants used for stress-related ailments in traditional zulu, xhosa and sotho medicine. Part 1: Plants used for headaches. J Ethnopharmacol 1994;43:89-124.
Bhat RB, Jacobs TV. Traditional herbal medicine in Transkei. J Ethnopharmacol 1995;48:7-12.
Hutchings A, Scott AH, Lewis G, Cunningham AB. Zulu Medicinal Plants: An Inventory. Pietermaritzburg: University of Natal Press; 1996.
Jäger AK, Hutchings A, van Staden J. Screening of zulu medicinal plants for prostaglandin-synthesis inhibitors. J Ethnopharmacol 1996;52:95-100.
Arnold TH, Prentice CA, Hawker LC, Snyman EE, Tomalin M, Crouch NR, et al. Medicinal and Magical Plants of Southern Africa: An Annotated Checklist. Pretoria: National Botanical Institute; 2002.
Cocks M, Dold AP. Cultural significance of biodiversity: The role of medicinal plants in urban African cultural practices in the Eastern Cape, South Africa. J Ethnobiol 2006;26:60-81.
Van Wyk BE, Gericke N. Peoples’ Plants: A Guide to Useful Plants of Southern Africa. Pretoria: Briza Publications; 2007.
van Wyk BE. A review of khoi-san and cape Dutch medical ethnobotany. J Ethnopharmacol 2008;119:331-41.
Aston Philander L. An ethnobotany of Western Cape rasta bush medicine. J Ethnopharmacol 2011;138:578-94.
Bhat RB. Plants of xhosa people in the Transkei region of Eastern Cape (South Africa) with major pharmacological and therapeutic properties. J Med Plants Res 2013;7:1474-80.
Bhat RB. Medicinal plants and traditional practices of xhosa people in the Transkei region of Eastern Cape, South Africa. Indian J Tradit Knowl 2014;13:292-8.
Mabona U, Van Vuuren SF. Southern African medicinal plants used to treat skin diseases. S Afr J Bot 2013;87:175-93.
Afolayan AJ, Grierson DS, Mbeng WO. Ethnobotanical survey of medicinal plants used in the management of skin disorders among the xhosa communities of the Amathole district, Eastern Cape, South Africa. J Ethnopharmacol 2014;153:220-32.
Lall N, Kishore N. Are plants used for skin care in South Africa fully explored? J Ethnopharmacol 2014;153:61-84.
Sewani-Rusike CR, Mammen M. Medicinal plants used as home remedies: A family survey by first year medical students. Afr J Tradit Complement Altern Med 2014;11:67-72.
Wintola OA, Afolayan AJ. An inventory of indigenous plants used as anthelmintics in Amathole district Municipality of the Eastern Cape province, South Africa. Afr J Tradit Complement Altern Med 2014;12:112-21.
Maroyi A. Diversity of use and local knowledge of wild and cultivated plants in the Eastern Cape province, South Africa. J Ethnobiol Ethnomed 2017;13:43.
Van Wyk BE, Gorelik B. The history and ethnobotany of Cape herbal teas. S Afr J Bot 2017;110:18-38.
Semenya SS, Maroyi A. Data on medicinal plants used to treat respiratory infections and related symptoms in South Africa. Data Brief 2018;21:419-23.
Maroyi A. Phytochemical and ethnopharmacological review of Heteropyxis natalensis. Asian J Pharm Clin Res 2019;12:8-15.
Maroyi A. Lannea schimperi: Review of its botany, medicinal uses, phytochemistry and biological activities. Asian J Pharm Clin Res 2019;12:31-6.
Loundou PM. Medicinal Plant Trade and Opportunities for Sustainable Management in the Cape Peninsula, South Africa. MSc Dissertation. Cape Town: University of Stellenbosch; 2008.
Scott G, Springfield EP, Coldrey N. A pharmacognostical study of 26 South African plant species used as traditional medicines. Pharm Biol 2004;42:186-213.
Giovanelli S, De Leo M, Cervelli C, Ruffoni B, Ciccarelli D, Pistelli L. Essential oil composition and volatile profile of seven Helichrysum species grown in Italy. Chem Biodivers 2018;15:e1800545.
Popoola OK. Chemical and Biological Characterization of South African Helichrysum species. PhD Thesis. Cape Town: University of the Western Cape; 2013.
Erasto P, Adebola P, Grierson D, Afolayan AJ. An ethnobotanical study of plants used for the treatment of diabetes in the Eastern Cape province, South Africa. Afr J Biotechnol 2005;4:1458-60.
Mahop MT, Mayet M. En route to biopiracy? Ethnobotanical research on anti diabetic medicinal plants in the Eastern Cape province, South Africa. Afr J Biotechnol 2007;6:2945-52.
Mudumbi JB, Ntwampe SK, Mekuto L, Matsha T, Itoba-Tombo EF. The role of pollutants in Type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies. Environ Monit Assess 2018;190:262.
Sabiu S, Madende M, Ajao AA, Ogundeji OA, Lekena N, Alayande KA. The scope of phytotherapy in Southern African antidiabetic healthcare. Trans R Soc S Afr 2019;74:1-18.
Lourens AC, Reddy D, Başer KH, Viljoen AM, Van Vuuren SF. In vitro biological activity and essential oil composition of four indigenous South African Helichrysum species. J Ethnopharmacol 2004;95:253-8.
Reddy D. The Phytochemistry and Antimicrobial Activity of Selected Indigenous Helichrysum species. MSc Dissertation. Johannesburg: University of the Witwatersrand; 2007.
Ras AM. Essential oil yield and composition of three Helichrysum species occurring in the Eastern Cape province of South Africa. S Afr J Bot 2013;86:181.
Lourens AC, Van Vuuren SF, Viljoen AM, Davids H, Van Heerden FR. Antimicrobial activity and in vitro cytotoxicity of selected South African Helichrysum species. S Afr J Bot 2011;77:229-35.
Sonka L. Exploring Anti-Tyrosinase Bioactive Compounds from the Cape flora. MSc Dissertation. Cape Town: University of the Western Cape; 2017.
Makhuvele R, Matshoga RG, Antonissen R, Pieters L, Verschaeve L, Elgorashi EE. Genotoxicity and antigenotoxicity of selected South African indigenous plants. S Afr J Bot 2018;114:89-99.
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