THE IMPACT OF 2-AMINOETHANESULFONIC ACID, GUARANINE METHYL THEOBROMINE 1, 3, 7-TRIMETHYLXANTHINE THEINE AND/OR ISOBUTYLPHENYL PROPIONIC ACID ON MASCULINE FECUNDITY, AND MORPHOPATHOLOGICAL DISORDERS IN RATS

Teratogenic effect of Ibuprofen, Taurine and Caffiene on Masculine Fecundity

  • WAEL ABU DAYYIH Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
  • YAZAN S BATARSEH Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
  • ZAINAB ZAKAREIA Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
  • MOHAMED HAMMAD Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Kingdom of Saudi Arabia.
  • KAMAL MANSI Department of Laboratory Medical Sciences, Faculty of Science, Al al-Bayt University, Mafraq, Jordan.
  • WALID ABU RAYYAN Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.

Abstract

Objectives: This study aims to evaluate the impact of caffeine (CAF), taurine (TUR), and ibuprofen (IBF) consumption on the masculine fecundity in rats and fetuses development.


Methods: The 1st group was kept as a normal control received distilled water. The 2nd, 3rd, and 4th groups received orally 250 mg/kg, 40 mg/kg, and 270 mg/kg of TUR, CAF, and IBF, respectively. In addition, the 5th, 6th, 7th, and 8th groups received TUR with CAF, TUR with IBF, CAF with IBF, and TUR, CAF, IBF combination, for 45 days. Blood samples were taken to determine testosterone and follicle-stimulating hormone levels and oxidation levels. Moreover, in testes, malondialdehyde and nitrite/nitrate were estimated. Besides, the abnormality of sperms, sperm counts, and percentage of sperm motilities was characterized. These masculines were allowed to mate with untreated masculine rats to determine the rate of pregnancy and study any malformation in their fetuses.


Results: The study revealed that each of CAF and/or IBF decreased the weights of fetuses, as well as sperm counts and motilities significantly. Besides, percentages of head and tail abnormalities were increased in CAF and/or IBF. The histopathological examination revealed the presence of marked degenerative changes in testes in CAF and/or IBF-treated groups.


Conclusion: CAF and IBF have a teratogenic effect on spermatozoa and masculine fecundity, whereas TUR almost improved undesirable impacts induced by IBF or/and CAF.

Keywords: Caffeine, Taurine, Ibuprofen, Fecundity, Masculine, Teratogenicity, Rats

References

1. Ohta A, Lukashev D, Jackson EK, Fredholm BB, Sitkovsky M 1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism. J Immunol 2007;179:7431-8.
2. Benedetti MD, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE, et al. Smoking, alcohol, and coffee consumption preceding Parkinson’s disease: A case-control study. Neurology 2000;55:1350-8.
3. Ross GW, Abbott RD, Petrovitch H, Morens DM, Grandinetti A, Tung KH, et al. Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA 2000;283:2674-9.
4. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999;51:83-133.
5. Foukas LC, Daniele N, Ktori C, Anderson KE, Jensen J, Shepherd PR, et al. Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities. J Biol Chem 2002;277:37124-30.
6. Harsha S, Ankita J, Harsha L, Deepak B. Anti-oxidative, anti-inflammatory and anti-atherosclerotic effect of taurine on hypercholesterolemia induced atherosclerotic rats. Int J Pharm Pharm Sci 2018;10:1-6.
7. Ripps H, Shen W. Review: Taurine: A “very essential” amino acid. Mol Vis 2012;18:2673-86.
8. Nittynen L, Nurminen ML, Korpela R, Vapaatalo H. Role of arginine, taurine and homocysteine in cardiovascular diseases. Ann Med 1999;31:318-26.
9. Ye R, Wang S, Li Y, Wu R, Pei J, Wang J, et al. Primary dysmenorrhea is potentially predictive for initial orthodontic pain in female patients. Angle Orthod 2014;84:424-9.
10. Abu Rayyan W. Influence of smoking duration on cadmium deposition in blood and scalp hair among university students in Jordan. Iran J Public Health 2016;45:266-7.
11. Abualhasan MN, Assali M, Zaid AN, Jaradat NA, Tarayra R, Hamdan A, et al. Synthesis and formulation of ibuprofen pro-drugs for enhanced transdermal absorption. Int J Pharm Pharm Sci 2015;7:352-4.
12. Velasco-Sosa YG, Villafuerte-Robles L. Effect of components and deposition on technological performance of ibuprofen tablets. Int J Appl Pharm 2018;10:62-8.
13. Kohli SS, Kohli VS. Effectiveness of piroxicam and ibuprofen premedication on orthodontic patients’ pain experiences. Angle Orthod 2011;81:1097-102.
14. Xiaoting L, Yin T, Yangxi C. Interventions for pain during fixed orthodontic appliance therapy. A systematic review. Angle Orthod 2010;80:925-32.
15. Grahame-Smith DG, Aronson JK, Oxford Textbook of Clinical Pharmacology and Drug Therapy. Oxford: Oxford University Press; 1992.
16. Gibson JD, Pumford NR, Samokyszyn VM, Hinson JA. Mechanism of acetaminophen-induced hepatotoxicity: Covalent binding versus oxidative stress. Chem Res Toxicol 1996;9:580-5.
17. El-Hady E, Kandil AM, Hassan WA, Ahmed AY. Comparative study of the effect of taurine, caffeine, and/or paracetamol on male fertility and teratogenicity in rats. J Pharm Pharm 2018;5:1-7.
18. Wassef B, Kohansieh M, Makaryus AN. Effects of energy drinks on the cardiovascular system. World J Cardiol 2017;9:796-806.
19. Zulli A, Smith RM, Kubatka P, Novak J, Uehara Y, Loftus H, et al. Caffeine and cardiovascular diseases: Critical review of current research. Eur J Nutr 2016;55:1331-43.
20. Bearden HJ, Fuquay JW. Applied Animal Reproduction. Reston, VA: Reston Publishing Company, Inc.; 1980.
21. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-11.
22. Barth R, Counce S, Smith P, Snell GD. Strong and weak histocompatibility gene differences in mice and their role in the rejection of homografts of tumors and skin. Ann Surg 1956;144:198-204.
23. McClain RM, Becker BA. Teratogenicity, fetal toxicity, and placental transfer of lead nitrate in rats. Toxicol Appl Pharmacol 1975;31:72-82.
24. Ghosal S, Chakraborty I, Pradhan NK. Jussiaea repens (L) induced morphological alterations in epididymal spermatozoa of rat. Int J Pharm Sci Rev Res 2013;22:288-95.
25. Bowman W, Rand M. The reproductive system and drugs affecting the reproductive systems. Textb Pharmacol 1985;20:1-8.
26. Ekaluo U, Ikpeme E, Udokpoh A. Sperm head abnormality and mutagenic effects of aspirin, paracetamol and caffeine containing analgesics in rats. Int J Toxicol 2009;7:1-9.
27. Krishnamoorthy P, Vaithinathan S, Rani VA, Bhuvaneswari A. Effect of Terminalia chebula fruit extract on lipid peroxidation and antioxidative system of testis of albino rats. Afr J Biotechnol 2007;6:1888-91.
28. Shashi A, Imtiaza K. Alleviation of fluoride induced alterations in antioxidant status and fecundity of spermatozoa of rates by Boerhaavia diffusa L. Int J Pharm Pharm Sci 2017;9:93-104.
29. Ratnasooriya WD, Jayakody JR. Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats. Asian J Androl 2000;2:247-55.
30. Rodemann HP, Goldberg AL. Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle. J Biol Chem 1982;257:1632-8.
31. Obochi GO, Amali OO, Ochalefu DO. Effect of melatonin and caffeine interaction on caffeine induced oxidative stress and sleep disorders. Niger J Physiol Sci 2010;25:17-24.
32. Vandenburgh HH, Shansky J, Solerssi R, Chromiak J. Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism. J Cell Physiol 1995;163:285-94.
Statistics
49 Views | 10 Downloads
How to Cite
WAEL ABU DAYYIH, YAZAN S BATARSEH, ZAINAB ZAKAREIA, MOHAMED HAMMAD, KAMAL MANSI, and WALID ABU RAYYAN. “THE IMPACT OF 2-AMINOETHANESULFONIC ACID, GUARANINE METHYL THEOBROMINE 1, 3, 7-TRIMETHYLXANTHINE THEINE AND/OR ISOBUTYLPHENYL PROPIONIC ACID ON MASCULINE FECUNDITY, AND MORPHOPATHOLOGICAL DISORDERS IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 11, Sept. 2019, pp. 113-8, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34898.
Section
Original Article(s)