TO STUDY THE IN VITRO INHIBITION OF BLOOD PLATELET AGGREGATION BY ISOLATED COMPOUNDS FROM CLAUSENA DENTATA (WILLD.) ROEM.

  • ANNAMALAI Maduram Sri sathya Sai Medical College & Research centre, kancheepuram (Dt) , Tamil Nadu, India
  • RAJU KAMARAJ Department of Pharmacognosy,SRM College of Pharmacy, SRM Institute of Science & Technology

Abstract

ABSTRACT


Objectives:  To study the anti- platelet aggregation activity of compounds isolated from extracts of Clausena dentata .Clausena (Rutaceae) is a genus of about 23 species of unarmed trees and shrubs. The stem bark of Clausena dentata is used in veterinary medicine for the treatment of wounds and sprains.Eventhough C. dentata has a lot of potential medical uses, the study of pharmacological properties is very scarce.  Methods: The plant C.dentata was collected in from Kadagaman, near Tiruvannamalai, Tamil Nadu, India and authenticated by Centre for Advanced Study in Botany, University of Madras, Chennai. The dry powder of stem bark was extracted with hexane, chloroform and methanol. The extracts were subjected to qualitative phytochemical screening and column chromatography. Four compounds were isolated. All the isolated compounds were subjected to Adenosine diphosphate (ADP) induced platelet aggregation and compared with Aspirin. Result.The isolated compounds from C. dentata and standard aspirin showed significant antiplatelet activity against ADP induced platelet aggregation.  Conclusion The compounds, 3-(1,1-dimethylallyl) xanthyletin , dentatin , nordentatin and carbazole showed significant antiplatelet aggregation activity. Among the compounds, nordentatin showed more activity of antiplatelet aggregation.


Key Words: C. Dentata, Coumarin, dentatin, ADP, Aspirin, platelet

Keywords: Key Words: C. Dentata, Coumarin, dentatin, ADP, Aspirin, platelet

Author Biographies

ANNAMALAI Maduram, Sri sathya Sai Medical College & Research centre, kancheepuram (Dt) , Tamil Nadu, India
Associate professor in pharmacology, Department of pharmacology, Sri sathya sai Medical college &Reseach Centre, kancheepuram (Dt), Tamil nadu, india
RAJU KAMARAJ , Department of Pharmacognosy,SRM College of Pharmacy, SRM Institute of Science & Technology
  1. . Department of Pharmacognosy,SRM College of Pharmacy, SRM Institute of Science & Technology, Kancheepuram (Dt), Chennai, Tamil Nadu, India Pin- 603203.

 

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Maduram, A., and RAJU KAMARAJ. “TO STUDY THE IN VITRO INHIBITION OF BLOOD PLATELET AGGREGATION BY ISOLATED COMPOUNDS FROM CLAUSENA DENTATA (WILLD.) ROEM.”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Oct. 2019, https://innovareacademics.in/journals/index.php/ajpcr/article/view/35557.
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