EVALUATION OF IN VIVO IMMUNOMODULATORY ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF CAPPARIS MOONII

  • VANITA G KANASE Department of ???, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.
  • SHRUTI SHETTIGAR Department of ???, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

Abstract

Objective: The present study was intended to evaluate the in vivo immunomodulatory activity of aqueous and ethanolic extract of dried fruits of Capparis moonii Wight.


Methods: The effect of both the extracts was evaluated by carbon clearance assay in mice, and they showed a significant increase in the phagocytic index at 50, 100, and 200 mg/kg dose. The effect of the extracts on delayed-type hypersensitivity (DTH) and antibody titer assay was evaluated in ovalbumin immunized mice.


Results: Both extracts showed a significant effect on DTH response and stimulation of antibody titer at 200 mg/kg dose. The effects of the extracts in cyclophosphamide-induced myelosuppression mice were also statistically significant.


Conclusion: The studies demonstrated specific and non-specific immunostimulating properties of both the ethanol and aqueous extract of C. moonii fruits in various in vivo experimental methods suggesting its therapeutic usefulness in immunocompromised conditions.

Keywords: Capparis moonii, Carbon clearance, Ovalbumin antibody titer, Cyclophosphamide myelosuppression

Author Biography

VANITA G KANASE, Department of ???, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

HOD Pharmacology.

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G KANASE, V., and S. SHETTIGAR. “EVALUATION OF IN VIVO IMMUNOMODULATORY ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF CAPPARIS MOONII”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 6, Apr. 2020, pp. 59-62, doi:10.22159/ajpcr.2020.v13i6.36031.
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