THE DIAGNOSTIC VALUE OF CONVENTIONAL TUBERCULOSIS DIAGNOSTIC PROCEDURE COMPARED WITH GENE X-PERT MTB/RIF: A CROSS-SECTIONAL STUDY

  • KETUT SURYANA Department of Internal Medicine, Wangaya Hospital in Denpasar, Bali, Indonesia.
  • HAMONG SUHARSONO Department of Biochemistry, Veterinary Faculty, Udayana University in Denpasar, Bali, Indonesia.
  • IDA BAGUS NGURAH RAI Department of Pulmonology, Medical Faculty, Udayana University - Sanglah Hospital in Denpasar, Bali, Indonesia.

Abstract

Objectives: The objectives of the study were to evaluate the diagnostic value of conventional tuberculosis (TB) diagnostic procedure compared with Gene X-pert Mycobacterium tuberculosis/rifampicin (MTB/RIF).


Methods: A cross-sectional study conducted from January to December 2018. The accuracy of conventional TB diagnostic procedure: TB screening, chest X-ray, and sputum Ziehl-Neelsen (ZN) staining was compared to Gene X-pert MTB/RIF using 2 × 2 table. p < 0.05 were taken as statistically significant. The collected data were processed using Statistical Package for the Social Science software version 26.0.


Results: A total of 117 participants suspected TB was found 44 (37.60%) confirmed TB. Among the suspected TB cases, 86 (73.50%) were male and 31 (26.50%) were female with the mean age of 43.86±16.47 years. The sensitivity and specificity of TB screening (prolonged cough) were 84.00% and 12.00%, respectively. Chest X-ray had the sensitivity and specificity (91.00%) and (10.00%). The sensitivity and specificity of sputum ZN were 57.00% and 99.00%.


Conclusions: Conventional TB diagnostic procedure has a high accuracy compared with Gene X-pert MTB/RIF. Therefore, it is still recommended as a TB diagnostic procedure routinely in era of Gene X-pert MTB/RIF, especially in Primary Health Care with limited settings.

Keywords: Pulmonary tuberculosis, Conventional tuberculosis diagnostic procedures, Gene X-pert Mycobacterium tuberculosis/rifampicin

Author Biographies

HAMONG SUHARSONO, Department of Biochemistry, Veterinary Faculty, Udayana University in Denpasar, Bali, Indonesia.

Department of Biochemistry, Veterinary Faculty at Udayana University in Denpasar, Bali, Indonesia

IDA BAGUS NGURAH RAI, Department of Pulmonology, Medical Faculty, Udayana University - Sanglah Hospital in Denpasar, Bali, Indonesia.

Department of Pulmonology, Medical Faculty of  Udayana University - Sanglah Hospital in Denpasar, Bali, Indonesia.

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SURYANA, K., H. SUHARSONO, and I. B. NGURAH RAI. “THE DIAGNOSTIC VALUE OF CONVENTIONAL TUBERCULOSIS DIAGNOSTIC PROCEDURE COMPARED WITH GENE X-PERT MTB/RIF: A CROSS-SECTIONAL STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 8, June 2020, pp. 138-41, doi:10.22159/ajpcr.2020.v13i8.37981.
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