Insulin resistance

  • BHAGYASHREE N Department of Physiology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
  • RAMASWAMY C Department of Physiology, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
  • RAMYA K Department of Physiology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.


Objective: Insulin resistance (IR) means a reduced ability of insulin to stimulate glucose utilization. IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD.

Methods: Total of 195 participants were recruited divided into three groups based on the presence of metabolic abnormalities as control Group I (with <3 components of metabolic syndrome [MS]), MS group as Group II (with any 3 components of MS), and severe MS as Group III (with more than three components of MS).

Results: Results showed that fasting blood sugar (FBS) and glycated hemoglobin showed a significant difference between the groups (p<0.001), whereas fasting insulin and IR were higher in severe MS which showed statistically significant difference (p<0.001) in comparison with control and MS group.

Conclusion: IR is one of the principal factors for the development of MS and further threw light that the increase in the IR level proportionately increases the severity of MS.

Keywords: Cardiovascular disease, Insulin resistance, Metabolic syndrome


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How to Cite
N, B., R. C, R. K, and G. M. “COMPARISON OF INSULIN RESISTANCE WITH THE SEVERITY OF METABOLIC SYNDROME”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 9, June 2020, pp. 73-75, doi:10.22159/ajpcr.2020.v13i9.38444.
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