COMPARISON OF INSULIN RESISTANCE WITH THE SEVERITY OF METABOLIC SYNDROME

Insulin resistance

  • BHAGYASHREE N Department of Physiology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
  • RAMASWAMY C Department of Physiology, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
  • RAMYA K Department of Physiology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
  • GANESH M

Abstract

Objective: Insulin resistance (IR) means a reduced ability of insulin to stimulate glucose utilization. IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD.


Methods: Total of 195 participants were recruited divided into three groups based on the presence of metabolic abnormalities as control Group I (with <3 components of metabolic syndrome [MS]), MS group as Group II (with any 3 components of MS), and severe MS as Group III (with more than three components of MS).


Results: Results showed that fasting blood sugar (FBS) and glycated hemoglobin showed a significant difference between the groups (p<0.001), whereas fasting insulin and IR were higher in severe MS which showed statistically significant difference (p<0.001) in comparison with control and MS group.


Conclusion: IR is one of the principal factors for the development of MS and further threw light that the increase in the IR level proportionately increases the severity of MS.

Keywords: Cardiovascular disease, Insulin resistance, Metabolic syndrome

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N, B., R. C, R. K, and G. M. “COMPARISON OF INSULIN RESISTANCE WITH THE SEVERITY OF METABOLIC SYNDROME”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 9, June 2020, pp. 73-75, doi:10.22159/ajpcr.2020.v13i9.38444.
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