• GUNJAN KUMAR MANDAL Assistant Professor, Department of Biochemistry, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • SANJAY BHATT Assistant Professor, Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.


Objectives: Metabolic syndrome (MetS) is a cluster of several metabolic disorders including hyperglycemia, reduced high-density lipoprotein cholesterol, and raised triglyceride level in serum, hypertension, and abdominal obesity. Glycated hemoglobin (HbA1c) is used as one of the diagnostic criteria for diabetes and diagnostic tool for MetS.

Methods: The present study was conducted at Prasad Institute of Medical Sciences. The study includes 150 patients with MetS as a case and 150 healthy volunteers as a control. MetS was diagnosed according to National Cholesterol Education Program’s Adult Treatment Panel III criteria. HbA1c was assayed in various components of MetS.

Results: It was found that HbA1c was significantly higher in MetS patients when compared to control group.

Conclusion: Our study suggests that HbA1c might be used as a diagnostic criterion for MetS. Therefore, proper glycemic control should be maintained by maintaining HbA1c level <6.5% to prevent from diabetes and MetS.

Keywords: Metabolic syndrome, Glycated hemoglobin, Diabetes


1. Shin JA, Lee JH, Lim SY, Ha HS, Kwon HS, Park YM. Metabolic syndrome as a predictor of Type 2 diabetes, and its clinical interpretations and usefulness. J Diabetes Invest 2013;4:334-43.
2. Sutkovic J, Nekic V. Study of HbA1c as a reliable indicator for metabolic syndrome in non diabetic patients. Southeast Eur J Soft Comput 2013;2:27-33.
3. Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract 2014;2014:943162.
4. Annani Akollor ME, Laing EF, Osei H, Mensah E, Owiredu EW, Afranie BO, et al. Prevalence of metabolic syndrome and the comparison of fasting plasma glucose and HbA1c as the glycemic criterion for MetS definition in non diabetic population in Ghana. Diabetol Metab Syndr 2019;11:26.
5. Oh HG, Rhee EJ, Kim TW, Lee KB, Park JH, Yang KI, et al. Higher glycated hemoglobin level is associated with increased risk for ischemic stroke in non-diabetic Korean male adults. Diabetes Metab J 2011;35:551-7.
6. Succurro E, Marini MA, Arturi F, Grembiale A, Fiorentino TV, Andreozzi F, et al. Usefulness of hemoglobin A1c as a criterion to define the metabolic syndrome in a cohort of Italian nondiabetic white subjects. Am J Cardiol 2011;107:1650-5.
7. Laclaustra M, Corella D, Ordovas JM. Metabolic syndrome pathophysiology: The role of adipose tissue. Nutr Metab Cardiovasc Dis 2007;17:125-39.
8. Saravia G, Civeira F, Hurtado-Roca Y, Andres E, Leon M, Pocovi M, et al. Glycated hemoglobin, fasting insulin and the metabolic syndrome in males. Cross-sectional analyses of the Aragon workers’ health study Baseline. PLoS One 2015;10:0132244.
9. Sung K, Rhee E. Glycated haemoglobin as a predictor for metabolic syndrome in non-diabetic Korean adults. Diabet Med 2007;24:848-54.
10. Siu P, Yuen Q. Supplementary use of HbA1c as hyperglycemic criterion to detect metabolic syndrome. Diabetol Metab Syndr 2014;6:119.
11. Ong K, Tso A, Lam K, Cherny S, Sham P, Cheung B. Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. Diabetes Care 2010;33:1856-8.
12. Janghorbani M, Amini M. Comparison of glycated hemoglobin with fasting plasma glucose in definition of glycemic component of the metabolic syndrome in an Iranian population. Diabetes Metab Syndr 2012;6:136-9.
50 Views | 86 Downloads
How to Cite
MANDAL, G. K., and S. BHATT. “GLYCATED HEMOGLOBIN LEVELS IN METABOLIC SYNDROME PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 11, Nov. 2020, pp. 101-3, doi:10.22159/ajpcr.2020.v13i11.39397.
Original Article(s)