A PROSPECTIVE OBSERVATIONAL STUDY ON THE INCIDENCE OF DRUG-RELATED HOSPITAL ADMISSIONS IN A TERTIARY CARE HOSPITAL
Keywords:Drug-related problems, Emergency admissions, Incidence, ADR, Non-adherence
Objectives: The objective of the study is to identify the incidence of drug-related problems coming to the EMD, classify, and identify the risk factor for DRP.
Methods: This was a prospective observational study conducted in the emergency department for a period of 6 months. The patients admitted through EMD with DRP were identified and then were classified according to Hepler and Strand, 1990 and Classen et al., 1997.
Results: A total of 109 patients were identified with DRP in our study. Among them, major part was contributed by ADRs (69.7%), non-adherence (27.5%) followed by sub-therapeutic dosage, and untreated indication and overdosage (0.91%). The major organ system involved in DRPs was found to be neurological system (26.60%) and gastrointestinal system (23.85%). The major causative drug class for DRP was found to be anti-thrombotic agents (27%), and the major risk factor for the development of DRP was found to be polypharmacy.
Conclusion: Drug-related problems are becoming one of the major reasons for the EMD admissions in the hospitals. It can cause significant burden to the society and to the health of the people.
Johnson JA, Bootman JL. Drug-related morbidity and mortality. A cost-of-illness model. Arch Intern Med 1995;155:1949-56.
Royal S, Smeaton L, Avery AJ, Hurwitz B, Sheikh A. Interventions in primary care to reduce medication related adverse events and hospital admissions: Systematic review and meta-analysis. Qual Saf Health Care 2006;15:23-31.
Busto U, Naranjo CA, Sellers EM. Comparison of two recently published algorithms for assessing the probability of adverse drug reactions. Br J Clin Pharmacol 1982;13:223-7.
Al-Arifi M, Abu-Hashem H, Al-Meziny M, Said R, Aljadhey H. Emergency department visits and admissions due to drug related problems at Riyadh Military Hospital (RMH), Saudi Arabia. Saudi Pharm J 2014;22:17-25.
Nair NP, Chalmers L, Peterson GM, Bereznicki BJ, Castelino RL, Bereznicki LR. Hospitalization in older patients due to adverse drug reactions -the need for a prediction tool. Clin Interv Aging 2016;11:497- 505.
Easton‐Carter KL, Chapman CB, Brien JE. Emergency department attendances associated with drug-related problems in paediatrics. J Paediatr Child Health 2003;39:124-9.
Kourorian Z, Fattahi F, Pourpak Z, Rasoolinejad M, Gholami K. Adverse drug reactions in an Iranian department of adult infectious diseases. East Mediterr Health J 2009;15:1351-7.
Krähenbühl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krähenbühl S. Drug-related problems in hospitals: A review of the recent literature. Drug Saf 2007;30:379-407.
Hohl CM, Dankoff J, Colacone A, Afilalo M. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann Emerg Med 2001;38:666-71.
Laisi U, Linnoila M, Seppälä T, Himberg JJ, Mattila MJ. Pharmacokinetic and pharmacodynamic interactions of diazepam with different alcoholic beverages. Eur J Clin Pharmacol 1979;16:263-70.
How to Cite
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.