FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLET OF PROPRANOLOL HYDROCHLORIDE USING MODIFIED TAMARIND SEED GUM AS A NATURAL SUPERDISINTEGRANT

Nisha Rani; DHRUV DEV

doi:10.22159/ajpcr.2022.v15i9.45284

Authors

Nisha Rani Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India.
DHRUV DEV Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i9.45284

Keywords:

Fast disintegrating tablet, Calcium complexed gum, Croscarmellose sodium, Disintegration time, Superdisintegrant

Abstract

Objective: The present study was carried out for the preparation of modified Tamarindus indica seed gum as a natural superdisintegrant and assessed various parameters for preparing a fast disintegrating dosage form.

Methods: The extracted gum from tamarind seeds was chemically modified by the carboxymethylation method. Then, calcium complexation of carboxymethyled tamarind seed gum was done. Fast disintegrating tablets were prepared by the direct compression method. The change in the functional groups of the extracted gum, Carboxymethyl tamarind seed gum, and the calcium complexed tamarind seed gum was studied by FT-IR spectrophotometer. DSC studies of calcium complexed tamarind seed gum showed alterations in the melting point without undergoing any modification.

Results: The pre-formulation studies such as physical appearance, swelling index, and viscosity of calcium complexed tamarind seed gum were characterized. From the studies, it was concluded that modified Tamarind seed gum was acidic and hydrophilic. The pH of the extracted tamarind seed gum was found to be 5.4. The fast disintegrating tablets were evaluated for hardness, friability, disintegration time, thickness, and in-vitro dissolution study. In the present study, the disintegration time of calcium complexed tamarind seed gum-containing tablets was compared with the marketed formulation of croscarmellose sodium as a synthetic superdisintegrant. The F5 formulation of calcium complexed tamarind seed gum showed a disintegration time of 37±2 s whereas the marketed formulation of croscarmellose sodium showed a disintegration time of 48±2 s.

Conclusion: It can be concluded that a fast disintegrating tablet prepared using calcium complexed Tamarind seed gum improves the disintegration time of the tablet.

Downloads

Download data is not yet available.

References

Desai PM, Liew CV, Heng PW. Review of disintegrants and the disintegration phenomena. J Pharm Sci 2016;105:2545-55. doi:10.1016/j.xphs.2015.12.019, PMID 27506604

Battu SK, Repka MA, Majumdar S, Madhusudan RY. Formulation and evaluation of rapidly disintegrating fenoverine tablets: Effect of superdisintegrants. Drug Dev Ind Pharm 2005;33:1225-32.

Mangal M, Thakral S, Goswami M, Ghai P. Superdisintegrants: An updated review. Int J Pharm Pharm Sci Res 2012;2:26-35.

Pahwa R, Gupta N. Superdisintegrant in the development of orally disintegrating tablets: A review. IJPSR 2011;2:2767-80.

Available from: https://www.pharmatutor.org/articles/ overviewsuperdisintegrants

Alam MT, Parvez N, Sharma PK. FDA-approved natural polymers for fast dissolving tablets. J Pharm (Cairo) 2014;2014:952970. doi: 10.1155/2014/952970, PMID 26556207

Shihora H, Panda S. Superdisintegrants utility in dosage forms: A quick review. J Pharm Sci Biosci Res 2011;1:148-53.

Singh R, Malviya R, Sharma PK. Extraction and characterization of tamarind seed polysaccharide as a pharmaceutical excipient. Pharmacogn J 2011;3:17-9. doi: 10.5530/pj.2011.20.4

Dash KD, Meher B, Roy A. A review on: Phytochemistry, pharmacology and traditional uses of Tamarindus indica. World J Pharm Pharm Sci 2014;10:229-40.

Mali K, Dhawale S, Dias R, Ghorpade V. Delivery of drugs using tamarind gum and modified tamarind gum: A review. Bull Fac Pharm 2019;57:1-24. doi: 10.21608/BFPC.2019.47260

Minkal AM, Ahuja M, Bhatt DC. Carboxymethyl gum katira: Synthesis, characterization and evaluation for nanoparticulate drug delivery. RSC Adv 2018;5:82363-73. doi: 10.1039/C5RA11702J

Reddy KM, Teja PB, Priya SM, Kumar KR, Govardhan UV. Extraction and evaluation of tamarind kernel mucilage powder for hydrocolloidal properties. Int J Adv Eng Res Sci 2018;5:177-82.

Ameena K, Dilip C, Saraswathi R, Krishnan PN, Sankar C, Simi SP. Isolation of the mucilages from Hibiscus rosa-sinensis L. and Okra (Abelmoschus esculentus L.) and studies of the binding effects of the mucilages. Asian Pac J Trop Med 2010;3:539-43. doi: 10.1016/S1995- 7645(10)60130-7

Ahuja M, Singh S, Kumar A. Evaluation of carboxymethyl gellan gum as a mucoadhesive polymer. Int J Biol Macromol 2013;53:114-21. doi: 10.1016/j.ijbiomac.2012.10.033, PMID 23178342

Dhruv D, Diksha R, Prasad DN. Calcium salt of carboxymethyled Aegle marmelos (bael fruit) gum: A novel superdisintegrant for fast disintegrating tablets. Asian J Pharm Res Dev 2018;6:67-72.

Rai PR, Tiwary AK, Rana V. Superior disintegrating properties of calcium cross linked cassia fistula gum derivative for fast dissolving tablet. Carbohydr Polym 2012;87:1098-104. doi: 10.1016/j. carbpol.2011.08.050

Puri A, Dev D, Prasad DN, Hira S, Sharma R. Modified Okra gum with silica: A novel superdisintegrant for fast disintegrating tablet. J Drug Deliv Ther 2019;9:206-11.

Bhatia NM, Salunkhe SS, Mali SS, Gadkari SS, Hajare AA, et al. Extraction and characterization of mucilage from Lepidium sativum L. Seeds. Sch Res Lib Pharm Lett 2014;6:65-70.

Waigh MP, Yewale CP, Zate SU, Kothawade PI, Mahale GH. Formulation and evaluation of fast dispersible tablets of aceclofenac using different superdisintegrant. Int J Pharm Sci 2010;2:154-7.

Kazarian SG, Chan KA. Applications of ATR-FTIR spectroscopic imaging to biomedical samples. Biochim Biophys Acta 2006;17: 858-67.

Venkateswarlu K, Preethi JK. Formulation development and in-vitro evaluation of mouth dissolving tablets of pioglitazone hydrochloride. Pharm Tutor 2016;4:37.

Jadhav D, Kharat R, Jhadav S, Patil MK. Design and evaluation of sustained release matrix tablet of propranolol hydrochloride. Indo Am J Pharm Res. 2015:1109-17.

Rowe RC, Paul JS, Sian CO. Handbook of Pharmaceutical Excipients. 6th ed. Washington, DC: Pharmaceutical Press; 2009. p. 45, 404, 424.

U S A Pharmacopeial Convention. National Formulary 35. United States Pharmacopeia 40. Rockville: United States Pharmacopeial Committee; 2017. p. 2886-8.

Aulton ME, Aulton’s Pharmaceutics the Design and Manufacture of Medicines. Philadelphia: Churchill Livingstone; 2013. p. 187-99.

Dnyaneshwar J, Kharat R, Jadhav S, Patil M. Design and evaluation of sustained release matrix tablet of propranolol hydrochloride. Indo Am J Pharm Res 2015;6876:2231.

Preethi GB, Banerjee S, Shivakumar HN, Kumar MR. Formulation of fast-dissolving tablets of doxazosin mesylate drug by direct compression method. Int J Appl Pharm 2017;9:22-8. doi: 10.22159/ ijap.2017v9i5.18168

Rajeshvar V, Ramana Mv. Formulation and evaluation of orodispersible rovustatin tablets: A comparative study on natural and synthetic superdisintegrants. Int J Pharm 2016;7:39-43.

Pandit V, Kashive D, Sharma TK. Formulation and evaluation of novel formulation for diabetes induced hypertension using modified innate superdisintegrant. J Drug Deliv Ther 2020;10:240-50. doi: 10.22270/ jddt.v10i5.4412

Shirshand SB, Ramani RG, Swamy PV. Novel co-processed super disintegrants in the design of fast dissolving tablets. Int J Pharm Biol Sci 2010;1:1-11.

Lachman L, Lieberman H, Kanig JL. Drying. In: Pharmaceutical Dosage Forms Tablet. Vol. 2. New York: Marcel Dekker; 1991. p. 4764.

Mohapatra S, Pattanaik P, Sudam C. Role of superdisintegrants for in-vitro characterization of loratadine orodispersible tablets. Int J Pharm Pharm Sci 2012;4:319-23.