COMPARATIVE STUDY OF FSH, LH, PROLACTIN, AND TSH INCASES OF PRIMARY INFERTILITY, CASES OF EARLY PREGNANCY LOSS, AND NORMAL FERTILE WOMEN

SEEMA; MANINDER KAUR; MANJIT KAUR MOHI

doi:10.22159/ajpcr.2023.v16i5.47027

Authors

SEEMA Department of Biochemistry, Government Medical College, Patiala, Punjab, India. https://orcid.org/0000-0003-0961-8643
MANINDER KAUR Department of Biochemistry, Government Medical College, Patiala, Punjab, India. https://orcid.org/0000-0002-8709-7575
MANJIT KAUR MOHI Department of Obstetrics and Gynaecology, Government Medical College, Patiala, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i5.47027

Keywords:

Infertility, Early pregnancy loss, Follicle-stimulating hormone, Luteinizing hormone, Prolactin, Thyroid-stimulating hormone

Abstract

Objectives: This study aimed to assess and compare follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and thyroid-stimulating hormone (TSH) levels in normal fertile females, patients with primary infertility, and patients with early pregnancy loss (EPL).

Methods: Patients were divided into three groups of 25 each. Group I consisted of patients of primary infertility, Group II consisted of patients of EPL, and Group C consisted of normal fertile females and acted as the control group. Hormone levels in different groups were compared statistically.

Results: FSH levels in the infertility group (Group I) and control group (Group C) were similar (p>0.05). The difference between the FSH levels of EPL (Group II) and the control group (Group C) was statistically significant (p<0.05). There was a statistically significant difference between LH levels of the infertility group (Group I), EPL (Group II), and control group (Group C) (p<0.05). The difference between prolactin levels of the infertility group (Group I), EPL (Group II), and control group (Group C) was also statistically significant (p<0.05). The difference between the TSH levels of the infertility group (Group I), EPL (Group II), and control group (Group C) was also statistically significant (p<0.05).

Conclusion: This study supports the fact that women with infertility and repeated abortions have altered hypothalamic–pituitary–ovarian axis as compared to fertile women.

Downloads

Download data is not yet available.

References

Katole A, Saoji AV. Prevalence of primary infertility and its associated risk factors in urban population of central India: A community-based cross-sectional study. Indian J Community Med 2019;44:337-41.

Available from: https://www.nhp.gov.in/disease/gynaecology-and-obstetrics/early-pregnancy-loss

Dutta DC, Chakravarty BN. Infertility. Textbook Gynaecology. 5th ed. Calcutta: New Central Book Agency (P) Ltd.; 2003. p. 212-40.

Bheem P, Dinesh P, Sharma NC. A study on serum FSH, LH and prolactin levels among infertile women. Int J Med Res Health Sci 2015;4:876-8.

Fupare S, Gadhiya BM, Jambhulkar RK, Tale A. Correlation of thyroid hormones with FSH, LH and prolactin in infertility in the reproductive age group women. Int J Clin Biochem Res 2015;2:216-22. doi: 10.5958/2394-6377.2015.00005.2

Doufas AG, Mastorakos G. The hypothalamic pituitary thyroid axis and the female reproductive system. Ann N Y Acad Sci 2000;900:65-76. doi: 10.1111/j.1749-6632.2000.tb06217.x, PMID 10818393

Artini PG, Uccelli A, Papini F, Simi G, Di Berardino OM, Ruggiero M, et al. Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity. Gynecol Endocrinol 2013;29:36-41. doi: 10.3109/09513590.2012.705391, PMID 22835333

Kundu S, Rao SS, Singh K, Rao R. Study of thyroid profile and prolactin levels in female infertility patients: An institutional analysis. J Sci Soc 2021;48:13-6.

Nasser AM, Al-Jumaili AZ, Alhusni ZK. The effect of pituitary hormones levels and relationship to female infertility in Baghdad Province. J Phys Conf Ser 2021;1853:012015. doi: 10.1088/1742- 6596/1853/1/012015.

Keerthanaa SR, Hiremath PB. Analytical study of thyroid and prolactin hormone levels in infertile women with menstrual irregularities. Int J Reprod Contracept Obstet Gynecol 2020;9(4):1328. doi: 10.18203/2320-1770.ijrcog20201025

Kataria J, Gill GK, Kaur M. Interrelationship of thyroid hormones, obesity and prolactin in infertile women. Asian J Pharm Clin Res 2018;11:136-7. doi: 10.22159/ajpcr.2018.v11i1.20861

Subhan M, Sadiq W, Subhan S. Prolactin, thyroid stimulating hormone (Ft3, Ft4) concentrations in female patients with infertility: An observational study. J Clin Exp Pathol 2017;7:6.

Al-Fahham AA, Al-Nowainy HQ. The role of FSH, LH and prolactin hormones in female infertility. Am J Pharm Tech Res 2016;6:110-8.

Şahin A, Önder F. Investigation of thyroid hormones and prolactin levels in fertile and infertile women. Middle Black Sea J Health Sci 2016;2:1-6. doi: 10.19127/mbsjohs.63680