EFFECT OF AQUEOUS EXTRACT OF PEEL OF CITRUS SINENSIS ON FROG’S HEART

  • Ratikanta Tripathy Assistant Professor, Dept. of Pharmacology, KIMS, BBSR, 751024
  • Manas Ranjan Pradhan
  • Basudev Lenka
  • Manjushree Mohanty

Abstract

Objectives: To evaluate the cardiotonic action of aqueous extract of the peel of Citrus sinensis and also to know the effect in the presence of propranolol,
nifedipine, and verapamil.
Methods: We studied the cardiotonic effect of citrus peel extracts on isolated frog heart perfusion technique alone and also with a continuous infusion
with calcium channel blockers and a beta blocker. The aqueous extract obtained by drying the peel of citrus and then adding the powder form in
distilled water.
Results: Aqueous extract produced positive ionotropic action on frog heart and its effect antagonized by propranolol but neither by nifedipine nor
verapamil.
Conclusion: Aqueous extract of peels of C. sinensis has cardiotonic activity and the cardiotonic effect produced by citrus may be due to having beta
adrenergic action.
Keywords: Digoxin, Cardiac stimulant, Isolated frog’s heart, Citrus sinensis.

Author Biography

Ratikanta Tripathy, Assistant Professor, Dept. of Pharmacology, KIMS, BBSR, 751024
Assistant Professor, Dept. of Pharmacology

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How to Cite
Tripathy, R., M. R. Pradhan, B. Lenka, and M. Mohanty. “EFFECT OF AQUEOUS EXTRACT OF PEEL OF CITRUS SINENSIS ON FROG’S HEART”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 84-86, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8546.
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Original Article(s)