EFFECT OF AQUEOUS EXTRACT OF PEEL OF CITRUS SINENSIS ON FROG'S HEART
Abstract
Objectives: To evaluate the cardiotonic action of aqueous extract of the peel of Citrus sinensis and also to know the effect in the presence of propranolol,
nifedipine, and verapamil.
Methods: We studied the cardiotonic effect of citrus peel extracts on isolated frog heart perfusion technique alone and also with a continuous infusion
with calcium channel blockers and a beta blocker. The aqueous extract obtained by drying the peel of citrus and then adding the powder form in
distilled water.
Results: Aqueous extract produced positive ionotropic action on frog heart and its effect antagonized by propranolol but neither by nifedipine nor
verapamil.
Conclusion: Aqueous extract of peels of C. sinensis has cardiotonic activity and the cardiotonic effect produced by citrus may be due to having beta
adrenergic action.
Keywords: Digoxin, Cardiac stimulant, Isolated frog's heart, Citrus sinensis.
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