• Iyan Sopyan Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran
  • Intan Mutiara Sari Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran
  • Insan Sunan K. Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran



Paracetamol, Chlorphenamine maleate, Polarization microscope, X-Ray diffraction, FT-IR


Objective: Interactions of active pharmaceutical ingredients (API) as well as pharmaceutical excipients don't occur in a pharmaceutical dosage form. Base on structures of paracetamol (PCT) and chlorphenamine maleate (CTM), its combination is possible to give a physical interaction in the solid state. This study was conducted to investigate the physical interaction of PCT and CTM in the solid state.

Methods: Characterization used the polarization microscope, solubility test, powder x-ray diffraction (PXRD) to observe peak shifting in 2ÆŸ angle, and fourier transform infrared spectroscopy (FT-IR) to examine wavenumber shifting.

Results: Results of solubility exhibited an increased solubility percentage with increasing concentration. Polarization microscope analysis presented a combination of crystal morphology after the two substances were mixed in an equimolar ratio. The result of melting point determination of each pure substance was 172 °C for PCT, 132 °C for CTM, and 170 °C for the mixture of the two substances in various ratios. Diffractogram showed the shifting at angle 2Ɵ: 20.715, 19.355-23.500 and 21.840, 26.455-20.330 for concentration ratio of PCT: CTM in (132:0.5) and (330:1) respectively and any change in the functional group was observed from infrared spectrum.

Conclusion: All evaluation of PCT and CTM in the solid state has exhibited the interaction in solid condition.


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How to Cite

Sopyan, I., Sari, I. M., & K., I. S. (2018). SOLID STATE CHARACTERIZATION OF A NOVEL PHYSICAL INTERACTION (PARACETAMOL-CHLORPHENIRAMINE MALEATE). International Journal of Applied Pharmaceutics, 10(1), 21–25.



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