PARENTERAL ANTIBIOTIC USAGE PATTERNS AND EFFECTS OF INTRAVENOUS TO ORAL SWITCHING ON THE LENGTH AND COST OF HOSPITALIZATION


Rengganis Pranandari, Sudibyo Supardi, Retnosari Andrajati

Abstract


Objective: The prolonged use of intravenous antibiotics might increase the length and cost of hospitalization. The research objective, therefore, was to
evaluate the effect of switching antibiotics on the length of hospital stay and hospitalization cost. The prospective cohort research design was adopted.
The inclusion criteria were in patients who had received intravenous antibiotics.
Methods: The sample comprised 39 patients who switched antibiotics as an exposed group and 39 patients who did not switch as an unexposed
group. The data were collected using the patient medical records and the financial data from the hospital information system. The Mann–Whitney test
and Chi-square or Fisher’s exact test was applied in the analysis.
Results: The results revealed that the antibiotics most commonly switched were intravenous ceftriaxone (83.3%) and oral cefixime (94.8%). From the
five switching patterns observed, the most common switch was from intravenous ceftriaxone to oral cefixime in patients with acute gastroenteritis.
All antibiotics were administered in accordance with the National Formulary (NF) guidelines. Only metronidazole (5 mg/ml dose) was inconsistent
with NF. Switching antibiotics did not impact the length of hospital stay and hospitalization cost; however, comorbidities did have an influence here.
Conclusions: Further, switching antibiotics impacted the duration over which intravenous antibiotics were administered and the cost of antibiotics.


Keywords


Switching antibiotics, Length of stay, Cost.

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hospitalization and cost of treatment

Variables n Mean Standard

deviation

p

Length of

hospitalization (days)

Age

Adult 65 5.69~6 2.24 0.591

Elderly 13 5.92~6 2.18

BMI

Underweight 11 5.91~6 2.62 0.907

Not underweight 67 5.70~6 2.17

Comorbidity

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Cost

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Comorbidity –2.011 –0.364 0.001

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p

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Non‑switching group 39 5.67 2.33

Cost (rupiah)

Switching group 39 46.478 51.947 0.003

Non‑switching group 39 114.781 169.660

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About this article

Title

PARENTERAL ANTIBIOTIC USAGE PATTERNS AND EFFECTS OF INTRAVENOUS TO ORAL SWITCHING ON THE LENGTH AND COST OF HOSPITALIZATION

Keywords

Switching antibiotics, Length of stay, Cost.

DOI

10.22159/ijap.2017.v9s1.44_50

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 85-89

Online ISSN

0975-7058

Statistics

6 Views | 15 Downloads

Authors & Affiliations

Rengganis Pranandari
Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Sudibyo Supardi
Centre of Public Health Intervention Technology, Agency for Health Research and Development, Ministry of Health, Indonesia.
Indonesia

Retnosari Andrajati
Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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