EVALUATION OF DRUG USE FOR RESPIRATORY PROBLEMS IN DEPOK, INDONESIA, BEFORE AND AFTER IMPLEMENTATION OF THE NATIONAL FORMULARY
DOI:
https://doi.org/10.22159/ijap.2018.v10s1.43Keywords:
Anatomical therapeutic chemicaldefined daily doses, Depok hospital, Drug utilization, National formularyAbstract
Objective: The aim of this study was to compare the quantity and quality of drug utilization (DU) in patients with respiratory problems at a hospital
in Indonesia before and after the implementation of the national formulary.
Methods: A cross-sectional retrospective study was conducted in 2013 and 2015 at the Depok Hospital in Indonesia. Prescriptions and data from
patients were recapitulated, reviewed, and evaluated using the anatomical therapeutical chemical classification/defined daily doses (DDDs) and
DU90% methodologies. The results were statistically analyzed and compared before and after implementation of the national formulary.
Results: The quantity of drug use in DDD/1000 inhabitant per day was increased from 0.17 to 0.26 between 2013 and 2015. The quality of drug
use was also increased following a decrease in the number of drugs in the DU90% segment. The percentage of drugs that adhered to the national
formulary was 88.67%; however, no significant difference was noted before and after the implementation of the national formulary.
Conclusion: The quantity, quality, and adherence of drug use to the national formulary was increased at the Depok city hospital after the implementation
of the national formulary.
Downloads
References
Indonesian Social Insurance Administration Organization. Republic
of Indonesia Law Number 24 of 2011. Indonesia: Indonesian Social
Insurance Administration Organization; 2011.
Plet HT, Hallas J, Kjeldsen LJ. Adherence to hospital drug formularies
and cost of drugs in hospitals in Denmark. Eur J Clin Pharmacol
;69:1837-43.
Ministry of Health. Pharmaceutical Care for Respiratory Tract
Infections. Jakarta: Ministry of Health, Republic of Indonesia; 2005.
World Health Organization Collaborating Centre for Drug Statistics
Methodology. Guidelines for ATC Classification and DDD Assignment.
In: Guidelines for ATC Classification and DDD Assignment, Oslo,
Norway. Oslo: World Health Organization Collaborating Centre for
Drug Statistics Methodology; 2016.
Wettermark B, Haglund K, Gustafsson LL, Persson PM, Bergman U.
A study of adherence to drug recommendations by providing
feedback of outpatient prescribing patterns to hospital specialists.
Pharmacoepidemiol Drug Saf 2005;14:579-88.
Catić T, Begović B. Outpatient antihypertensive drug utilization in
canton Sarajevo during five years period (2004-2008) and adherence to
treatment guidelines assessment. Bosn J Basic Med Sci 2011;11:97-102.
Horvat O, Mijatović V, Čalasan J, Sabo A. Outpatient utilization of
non-steroidal anti-inflammatory drugs in three largest municipalities in
South Backa district. SRPSKI Arh Celok Lek 2012;140:339-43.
Sastra S, Irsa L, Loebis MS, Evalina R. Number of siblings and allergic
rhinitis in children. Paediatr Indones 2016;56:1-7.
Aït-Khaled N, Pearce N, Anderson HR, Ellwood P, Montefort S, Shah J,
et al. Global map of the prevalence of symptoms of rhinoconjunctivitis
in children: the international study of asthma and allergies in childhood
(Isaac) phase three. Allergy 2009;64:123-48.
Zhang L, Cheng L, Hong J. The clinical use of cetirizine in the treatment
of allergic rhinitis. Pharmacology 2013;92:14-25.
Ciprandi G, Tosca M, Ricca V, Passalacqua G, Fregonese L, Fasce L,
et al. Cetirizine treatment of allergic cough in children with pollen
allergy. Allergy 1997;52:752-4.
British Medical Association. BMJ Group and the royal
pharmaceutical. Committee, joint formulary. In: British National
Formulary 68; 2014 Society of Great Britain. England: British
Medical Association; 2014.
Fashner J, Ericson K, Werner S. St Joseph and family medicine. Treatment
of the common cold in children and adults. Am Fam Phys 2012;86:153-9.
Strand TA, Taneja S, Bhandari N, Refsum H, Ueland PM, Bahl R, et al.
Folate, but not Vitamin B-12 status, predicts respiratory morbidity in
North Indian children. Am J Clin Nutr 2007;7:139-44.
de Benedictis FM, Bush A. Corticosteroids in respiratory diseases in
children. Am J Respir Crit Care Med 2012;185:12-23.
Published
How to Cite
Issue
Section
