EFFICACY OF MOUTH RINSE FORMULATION BASED ON CETYLPYRIDINIUM CHLORIDE 0.1% IN THE CONTROL OF DENTAL CALCULUS BUILDUP


Diah Ayu Maharani, Alia Ramadhani, Melissa Adiatman, Yuniardini Septorini Wimardhani, Linda Kusdhany, Anton Rahardjo, Izzet Yavuz

Abstract


Objective: This study aimed at comparing the antiplaque, anticalculus, and antigingivitis potentials of a mouth rinse containing essential oil, alcohol,
zinc, and fluoride with a mouth rinse containing cetylpyridinium chloride (CPC) 0.1% over 1-, 2-, and 3-month periods.
Methods: This study was a double-blind, parallel randomized clinical trial with a 3-day run-in phase. Respondents were asked to gargle twice daily
with 15 ml of mouth rinse for 30 seconds after brushing teeth. Respondents were 80 females with a mean age of 21 years, and a single dental examiner
was employed throughout the study to decrease the variance. Prophylaxis was performed for all respondents before the intervention. Three mouth
rinses were tested: Group 1 with the mouth rinse containing CPC 0.1%, Group 2 as the negative control, and Group 3 as the positive control with a
mouth rinse containing alcohol. Evaluations were conducted by plaque index, gingival index, calculus index, and CariScreen examinations.
Results: The clinical trial showed that the mouth rinse with alcohol and the mouth rinse containing CPC 0.1% were effective in inhibiting bacterial
buildup (antiplaque) and have anticalculus properties, but with no statistically significant antigingivitis effect.
Conclusion: It was found that the mouth rinse containing alcohol has similar effectiveness with CPC 0.1% mouth rinse, but side effects, such as a
burning sensation, were reported in the alcohol-containing mouth rinse.


Keywords


Mouth rinse, Cetylpyridinium chloride, Anticalculus.

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About this article

Title

EFFICACY OF MOUTH RINSE FORMULATION BASED ON CETYLPYRIDINIUM CHLORIDE 0.1% IN THE CONTROL OF DENTAL CALCULUS BUILDUP

Keywords

Mouth rinse, Cetylpyridinium chloride, Anticalculus.

DOI

10.22159/ijap.2017.v9s1.84_91

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 176-180

Online ISSN

0975-7058

Statistics

10 Views | 23 Downloads

Authors & Affiliations

Diah Ayu Maharani
Department of Preventive and Public Health Dentistry, Faculty of Dentistry, Universitas Indonesia, Depok, Indonesia.
Indonesia

Alia Ramadhani
Oral Epidemiology and Clinical Studies in Dentistry Research Cluster, Faculty of Dentistry, Universitas Indonesia, Depok, Indonesia.
Indonesia

Melissa Adiatman
Department of Preventive and Public Health Dentistry, Faculty of Dentistry, Universitas Indonesia, Depok, Indonesia.
Indonesia

Yuniardini Septorini Wimardhani
diah.ayu64@ui.ac.id
Indonesia

Linda Kusdhany
Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Depok, Indonesia.
Indonesia

Anton Rahardjo
Department of Preventive and Public Health Dentistry, Faculty of Dentistry, Universitas Indonesia, Depok, Indonesia.
Indonesia

Izzet Yavuz
Department of Pediatric Dentistry, Faculty of Dentistry, University of Dicle, Diyarbakır, Turkey.


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