DEVELOPMENT AND EVALUATION OF NANOSPONGE LOADED TOPICAL HERBAL GEL OF WRIGHTIA TINCTORIA
Objective: Psoriasis is the most common chronic autoimmune disease. The main objective of the present study was to develop Nanosponge (NS) based Topical gels of Wrightia tinctoria extract using cross-linker and polymer by melting method. It is used in treating Psoriasis.
Methods: Phytoconstituents present in the herbal extract were identified by Liquid Chromatography-Mass Spectroscopy (LC-MS) studies. In vitro drug release and Entrapment Efficiency of all NS were determined. The optimized NS were incorporated in the gel to formulate nano topical gel. Evaluation studies like homogenicity, viscosity, spreadability, pH and In vitro studies were carried out for all gel formulations.
Results: The prepared gels were transparent, had good viscosity and spreadability. SEM photographs confirmed that the prepared formulation were roughly spherical and porous in nature. In vitro diffusion studies showed drug release of 92.15% in 24 h.
Conclusion: From this study it can be concluded that constituents responsible for treating psoriasis are present in the obtained extract and prepared NS based topical gel has significant effect in providing sustained drug release.
2. Eman SEL, Amna MM, Abeer MK, Doaa GH. Nanoemulsion gel of nutraceutical co-enzyme q10 as an alternative to the conventional topical delivery system to enhance skin permeability and anti-wrinkle efficiency. Int J Pharm Pharm Sci 2017;9:207-11.
3. Sanaa EG, Maha F, Basma M, Fatma EZ. Betamethasone dipropionate gel for the treatment of localized plaque psoriasis. Int J Pharm Pharm Sci 2017;9:173-82.
4. Vyas SP, Khar RK. Targeted and controlled drug delivery novel carrier systems. CBS publishers and distributors, N. Delhi; 2002;2:346-8.
5. Madhuri S, Sunil KP, Alok M, Shashi A, Poonam Y, Amita V. Nanosponges: a potential nanocarrier for novel drug delivery-a review. Asian Pac J Trop Dis 2015;5:23-30.
6. Nikita S, Vishal GN, Sandeep K. A review on nanosponges a review on nanosponges: a boon to targeted drug delivery for an anticancer drug. Asian J Pharm Clin Res 2019;12:1-7.
7. Ashwini D, Pritesh P. Preparation and evaluation of cyclodextrin based Atorvastatin. Am J Pharm Tech Res 2014;4:570-87.
8. Sailaja G, Swathi CK, Darshini SB. Evaluation of release retarding efficiency of olibanum gum-a natural polymer in comparison to known polymers. Int J Pharm Ind Res 2014;4:33-8.
9. Selvakumar S, Sanjeet KS. Preliminary phytochemical screening of wrightia tinctoria. Res J Pharm Bio Chem Sci 2016;7:8-11.
10. Nagalakshmi HS, Arijit D, Sourav B. In vitro antimicrobial properties and phytochemical evaluation of mature seed extracts of wrightia tinctoria. J Pure Appl Microbiol 2012;6:1273-9.
11. Jain PS, Bari SB. Isolation of lupeol, stigmasterol and campesterol from petroleum ether extract of woody stem of wrightia tinctoria. Asian J Plant Sci 2010;9:163-7.
12. Mahendra SK, Nityanand PV. Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile. J Coast Life Med 2014;2:82640.
13. Rajani S. A review on phytochemical, pharmacological, and pharmacognostical profile of Wrightia tinctoria: adulterant of kurchi. Phcog Rev 2014;8:36-4.
14. Khalid AA, Pradeep RV, Francesco T, Roberta C. Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterization, stability, cytotoxicity and permeation study. AAPS PharmSciTech 2011;12:279-86.
15. Darandale SS, Vavia PR. Cyclodextrin-based nanosponges of curcumin: formulation and physicochemical characterization. J Incl Phenom Macrocycl Chem 2013;75:315-22.
16. Ansari KA, Pradeep RV, Francesco T, Roberta C. Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterization, stability, cytotoxicity and permeation study. AAPS PharmSciTech 2011;12:279-86.
17. Subhash Chandra BP, Nagaraju R, Saritha D, Sailakshmi B, Srikanth R. Formulation and evaluation of lansoprazole loaded nanosponges. Turk J Pharm Sci 2016;13:304-10.
18. Sarfaraz A. Formulation and evaluation of clobetasol propionate loaded nanoemulsion gel containing tea tree oil. World J Pharm Pharm Sci 2016;5:616-28.
19. Phatak AA, Chaudhari PD. Development and evaluation of nanogel as a carried for transdermal delivery of aceclofenac. Asian J Pharm Tech 2012;2:125-32.
20. Chetan GS, Pramod kumar TM, Venkatesh MP. Intra-articular delivery of methotrexate loaded nanostructured lipid carrier-based smart gel for effective treatment of rheumatic diseases. RSC Adv 2016;16:1-43.
21. Zhang X, Pan W, Gan L. Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxy-camptothecin by spray-drying. Chem Pharm Bull 2008;56:1645-50.
22. Joshi M, Pathak S, Sharma S, Patravale V. Design and in vivo pharmacodynamic evaluation of nanostructured lipid carriers for parenteral delivery of artemether: nanoject. Int J Pharm 2008;364:119-26.
This work is licensed under a Creative Commons Attribution 4.0 International License.