• Tashatai Prasertpol Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
  • Waree Tiyaboonchai The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on High Education, Ministry of Education, Thailand



Nanostructured lipid carriers, Human hair, Split-end, Leave-on product


Objective: This study aimed to develop the nanostructured lipid carriers (NLCs) for repairing the hair split-end and to compare the influence of NLCs charges on hair binding effects.

Methods: NLCs was prepared by a high-pressure homogenization technique. The difference solid lipids were selected to obtain the negatively charged NLCs (N-NLCs) and positively charged NLCs (P-NLCs). The physical characterizations of both NLCs were examined. The NLCs cream was prepared by mixing NLCs into a cream base. Then, the hair split-end binding effects of the NLCs cream were assessed. The physical stability of both NLCs were investigated by kept at room temperature for 6 mo.

Results: The N-NLCs and P-NLCs were successfully prepared with a zeta potential of -44.4 mV and 32.3 mV, respectively. They were a spherical shape with a similar mean size of ~150-160 nm. The hair split-end evaluation showed that both NLCs illustrated similar hair split-end binding time of more than 3 d, suggesting no extra benefit from the positively charged of P-NLCs. On the contrary, the cream base and commercial product showed a short binding time of <8 h. Furthermore, after 6-mo storage, N-NLCs demonstrated good physical stability without particle aggregation, while P-NLCs exhibited a phase separation.

Conclusion: The developed NLCs is a novel alternative for the leave-on product, which would be highly benefits for hair split-end repairing.


Richena M, Rezende CA. Morphological degradation of human hair cuticle due to simulated sunlight irradiation and washing. J Photochem Photobiol B Biol 2016;161:430–40.

Richena M, Rezende CA. Effect of photodamage on the outermost cuticle layer of human hair. J Photochem Photobiol B Biol 2015;153:296–304.

Swift JA. The mechanics of fracture of human hair. Int J Cosmet Sci 1999;21:227–39.

Bhushan B. Nanoscale characterization of human hair and hair conditioners. Prog Mater Sci 2008;53:585–710.

Wright M, Szerszen M. Ending the cycle of split ends. Cosmetics Toiletries 2011;126:804–9.

Mahajan A. Advancements in polymers used in hair care: a review. Int J Res Cosmet Sci 2016;6:6–16.

Nazir H, Wang L, Lian G, Zhu S, Zhang Y, Liu Y, et al. Multilayered silicone oil droplets of narrow size distribution: preparation and improved deposition on hair. Colloids Surfaces B: Biointerfaces 2012;100:42–9.

Gavazzoni Dias MF. Hair cosmetics: an overview. Int J Trichol 2015;7:2–15.

Dario MF, Baby AR, Velasco MVR. Effects of solar radiation on hair and photoprotection. J Photochem Photobiol B Biol 2015;153:240–6.

Duarah S, Pujari K, Durai RD, Narayanan VHB. Nanotechnology-based cosmeceuticals: a review. Int J Appl Pharm 2016;8:8–12.

Mehnert W, Mader K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Delivery Rev 2012;64(Suppl):83–101.

Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A. Nanostructured lipid carriers (NLC): a potential delivery system for bioactive food molecules. Innov Food Sci Emerg Technol 2013;19:29–43.

Pardeike J, Hommoss A, Müller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 2009;366:170–84.

Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Delivery Rev 2002;54(Suppl):131–55.

Müller RH, Petersen RD, Hommoss A, Pardeike J. Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv Drug Delivery Rev 2007;59:522–30.

Mehnert W, Mader K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Delivery Rev 2012;64(Suppl):83–101.

Niamprem P, Srinivas SP, Tiyaboonchai W. Development and characterization of indomethacin-loaded mucoadhesive nanostructured lipid carriers for topical ocular delivery. Int J Appl Pharm 2018;10:91–6.

Seyfoddin A, Al-Kassas R. Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir. Drug Dev Ind Pharm 2013;39:508–19.

Huang ZR, Hua SC, Yang YL, Fang JY. Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion. Acta Pharmacol Sin 2008;29:1094–102.

Katainen J, Paajanen M, Ahtola E, Pore V, Lahtinen J. Adhesion as an interplay between particle size and surface roughness. J Colloid Interface Sci 2006;304:524–9.

Ranade MB. Adhesion and removal of fine particles on surfaces. Aerosol Sci Technol 1987;7:161–76.

Yang Y, Corona A, Schubert B, Reeder R, Henson MA. The effect of oil type on the aggregation stability of nanostructured lipid carriers. J Colloid Interface Sci 2014;418:261–72.

Campbell RB, Balasubramanian SV, Straubinger RM. Phospholipid-cationic lipid interactions: influences on membrane and vesicle properties. Biochim Biophys Acta Biomembr 2001;1512:27–39.



How to Cite

Prasertpol, T., & Tiyaboonchai, W. (2019). DEVELOPMENT AND CHARACTERIZATION OF CREAM CONTAINING NANOSTRUCTURED LIPID CARRIERS FOR HAIR SPLIT-END REPAIRING. International Journal of Applied Pharmaceutics, 11(4), 354-358.



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