DEVELOPMENT, CHARACTERIZATION AND SKIN IRRITATION OF MANGOSTEEN PEEL EXTRACT SOLID DISPERSION CONTAINING CLAY FACIAL MASK


Suchiwa Pan-on, Soravoot Rujivipat, Anan Ounaroon, Chuenjid Kongkaew, Waree Tiyaboonchai

Abstract


Objective: To develop clay facial mask containing mangosteen peel extract solid dispersion (MPESD) for enhancing α-mangostin bioavailability and to determine suitable clay based facial mask.

Methods: The MPESD were prepared by melting solvent method employing PVP K30 and poloxamer 188 as a carrier. The water solubility was determined by HPLC method. The in vitro skin permeability was examined using porcine ear epidermis. The effects of clay types on physical stability of MPESD and α-mangostin adsorption capacity were evaluated. The skin irritation was determined by 4 h human patch test.

Results: After dissolved optimal formulation of MPESD in water, the spherical micelle was observed with a mean size of ~150 nm and showed significantly α-mangostin water solubility enhancement of ~7 mg/ml, 700 times greater than MPE. Upon mixing the MPESD with clays, a dry powder was obtained. In vitro permeation studies of the MPESD mixed with titanium dioxide showed lowest α-mangostin permeation, while MPESD mixed with mica or talcum showed similar permeation profile as free MPESD solutions. No sign of skin irritation was observed in volunteers after application of the MPESD-based clay facial mask patch on the inner forearm skin for 4 h.

Conclusion: MPESD demonstrate a promising technique for improving water solubility and permeation of α-mangostin which reducing staining effect. In addition, it is safe for topical application and cosmetically acceptable.

 


Keywords


α-mangostin, clay, facial mask, permeation, solid dispersion

References


Bergaya F, Theng BKG, Lagaly G, editors. Handbook of Clay Science. Amsterdam: Elsevier; 2006.

Pothitirat W, Chomnawang MT, Supabphol R, Gritsanapan W. Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity. Fitoterapia 2009;80:442-7.

Márquez-Valadez B, Lugo-Huitrón R, Valdivia-Cerda V, Miranda-Ramírez LR, Pérez-De La Cruz V, González-Cuahutencos O, et al. The natural xanthone α-mangostin reduces oxidative damage in rat brain tissue. Nutr Neurosci 2009;12:35-42.

Ngawhirunpat T, Opanasopi P, Sukma M, Sittisombut C, Kat A, Adachi I. Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana). Pharm Biol 2010;48:55-62.

Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol 2008;46:3227-39.

Aisha AFA, Ismail Z, Abu-salah KM, Majid AMSA. Solid dispersions of α-mangostin improve its aqueous solubility through self-assembly of nanomicelles. J Pharm Sci 2012;101:815-25.

Vo CL-N, Park C, Lee B-J. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm 2013;85:799-813.

Jessie Sofia Pamudji SW, Meisa Handini Tampara. Improvement of gliclazide's dissolution rate by using surface solid dispersion with avicel PH 101. Int J Pharm Pharm Sci 2014;6:461-5.

Basketter DA, York M, McFadden JP, Robinson MK. Determination of skin irritation potential in the human 4-h patch test. Contact Derm 2004;51:1-4.

Fitzpatrick S, McCabe JF, Petts CR, Booth SW. Effect of moisture on polyvinylpyrrolidone in accelerated stability testing. Int J Pharm 2002;246:143-51.

Lu Y, Tang N, Lian R, Qi J, Wu W. Understanding the relationship between wettability and dissolution of solid dispersion. Int J Pharm 2014;465:25-31.

Salman A, Nasrul E, Rrival H, Ben ES, Zaini E. Physicochemical characterization of amorphous solid dispersion of ketoprofen-polyvinylpyrrolidone K-30. Int J Pharm Pharm Sci 2015;7:209-12.

Chisti Y. Poloxamers and poloxamines in nanoparticle engineering and experimental medicine. Trends Biotechnol 2000;18:412-20.

Maraie NK, Alhamdany AT, Radhi AA. Efficacy of combination solid dispersion technology on dissolution performance of nalidixic acid and cefdinir. Asian J Pharm Clin Res 2017;10:394-401.

Vyas V, Sancheti P, Karekar P, Shah M, Pore Y. Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407. Acta Pharm 2009;59:453–61.

Agner T. Basal transepidermal water loss, skin thickness, skin blood flow and skin colour in relation to sodium-lauryl-sulphate- induced irritation in normal skin. Contact Derm 1991;25:108-14.

Fartasch M, Schnetz E, Diepgen TL. Characterization of Detergent-Induced Barrier Alterations — Effect of Barrier Cream on Irritation. J Investig Dermatol Symp Proc 1998;3:121-7.




Fatal error: Call to a member function getGalleyLabel() on null in /home/innowar1/public_html/journals/cache/t_compile/%%38^38D^38D7420B%%article.tpl.php on line 182