FORMULATION AND CHARACTERIZATIONS OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF EXTRACT PETIVERIA ALLIACEA (SINGAWALANG) LEAVES

  • ARIFA MUSTIKA Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Prof. Moestopo 47, Surabaya, Indonesia.
  • NURMAWATI FATIMAH Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Prof. Moestopo 47, Surabaya, Indonesia.
  • GADIS MEINAR SARI Department of Physiology, Faculty of Medicine, Universitas Airlangga, Prof. Moestopo 47, Surabaya, Indonesia.

Abstract

Objective: Formulation of Singawalang leaves extract should be considered because the extract contains a variety of compounds so that there may
be a competitor in the absorption process and will cause the absorption of active ingredients in the gastrointestinal decline. One way to increase the
absorption and disposition of active ingredients on target organs is to use a nanoparticle formulation. Therefore, this study will conduct research on
self-nanoemulsifying drug delivery system (SNEDDS) formulation of Singawalang (Petiveria alliacea) leaves extract.
Methods: The systems were developed by investigating the solubility Singawalang leaves extract in various carrier oil, the suitable surfactant,
and cosurfactant, construction of SNEDDS of Singawalang leaves extract and characterization of droplet size through particle size analyzer and
transmission electron microscopy.
Results: The results of this study indicate that the optimum carrier oils for Singawalang leave extract are miglitol and virgin coconut oil (VCO),
the compatible surfactant component is tween 80 and the compatible cosurfactant is propylene glycol (PG). The average droplet size is 13 nm and
polydisperse index 0,004 and 0,006.
Conclusion: It can be concluded, the present study demonstrated that the optimum SNEDDS formulations of Singawalang leave extract are the
mixture of VCO, tween 80, PG at ratio 1:8:1 and miglitol, tween 80, and PG at ratio 2:5:3.

Keywords: Petiveria alliacea, Self-nanoemulsifying drug delivery system, Miglitol, Virgin coconut oil

References

1. Barbosa-Filho JM, Vasconcelos TH, Alencar AA, Batista LM,
Oliveira RA, Guedes DN, et al. Plants and their active constituents
from South, central, and North America with hypoglycemic activity.
Braz J Pharmacogn 2005;15:392-413.
2. Domínguez DR, Heredia LB, Martínez EC, Lores RI. Efecto del
extracto hipoglicemeante de petiveria alliacea l sobre el consumo de
glucosa por los eritrocitos. Rev Cubana Invest Biomed 2002;21:161-6.
3. Mustika A, Indrawati R, Sari GM. Effect of Petiveria alliacea leaves
extracts in decreasing serum level of blood glucose level through
activation of AMPK-?1 in diabetes mellitus rat models. Indones J Clin
Pharm 2017;6:22-31.
4. Kumar R, Sharma M. Herbal nanomedicine interactions to enhance
pharmacokinetics, pharmacodynamics, and therapeutic index for better
bioavailability and biocompatibility of herbal formulations. J Mater
Nanosci 2018;5:35-58.
5. Watkins R, Wu L, Zhang C, Davis RM, Xu B. Natural product-based
nanomedicine: Recent advances and issues. Int J Nanomedicine
2015;10:6055-74.
6. Sundari, Zuprizal, Yuwanta T, Martien R. Formulation nanocapsule of
turmeric extract characterization on oral administration and its ability
as antibacterial. Int J Sci Eng Res 2014;5:1261-5.
7. Mg K, Krenn V, Huebner F. History and possible uses of nanomedicine
based on nanoparticles and nanotechnological progress. J Nanomed
Nanotechnol 2015;6:06.
8. Mamillapalli V, Atmakuri AM, Khantamneni P. Nanoparticles for
herbal extracts. Asian J Pharm 2016;10:54.
9. Martien R, Adhyatmika A, Irianto ID, Farida V, Sari DP. Technology
developments nanoparticles as drug delivery systems. Majalah
Farmaseutik 2012;8:133-44.
10. Ober CA, Gupta RB. Nanoparticle technology drug delivery. Idea@s
CONCYTEG 2011;6:714-26.
11. Meena KP, Dangi PK, Kumar M. Nanoparticles technology and recent
advances in novel drug delivery systems. Int J Res Drug Deliv 2011;1:1-5.
12. Balakumar K, Raghavan CV, selvan NT, prasad RH, Abdu S. Self
nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin
calcium: Design, formulation, bioavailability and pharmacokinetic
evaluation. Colloids Surf B Biointerfaces 2013;112:337-43.
13. Bonifácio BV, Silva PB, Ramos MA, Negri KM, Bauab TM,
Chorilli M, et al. Nanotechnology-based drug delivery systems and
herbal medicines: A review. Int J Nanomedicine 2014;9:1-5.
14. Liu C, Lv L, Guo W, Mo L, Huang Y, Li G, et al. Self-nanoemulsifying
drug delivery system of tetrandrine for improved bioavailability:
Physicochemical characterization and pharmacokinetic study. Biomed
Res Int 2018;2018:6763057.
15. Qian J, Meng H, Xin L, Xia M, Shen H, Li G, et al. Self-nanoemulsifying
drug delivery systems of myricetin: Formulation development,
characterization, and in vitro and in vivo evaluation. Colloids Surf B
Biointerfaces 2017;160:101-9.
16. Avachat AM, Patel VG. ZSPJ: The official publication. Saudi Pharm
Soc 2015;23:276-89.
17. Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY, et al. AMPactivated
protein kinase regulates neuronal polarization by interfering
with PI 3-kinase localization. Science 2011;332:247-51.
18. Ujilestari T, Martien R, Ariyadi B, Dono ND, Zuprizal. Self-nano
emulsifying drug delivery system [SNEDDS] of Amomum compactum
essential oil: Design, formulation, and characterization. J Appl Pharm
Sci V 2018;8:14-21.
19. Kalantari A, Kósa D, Nemes D, Ujhelyi Z, Fehér P, Vecsernyés M,
et al. Self-nanoemulsifying drug delivery systems containing Plantago
lanceolata an assessment of their antioxidant and antiinflammatory
effects. Molecules 2017;22:E1773.
20. Boulaiz H, Alvarez PJ, Ramirez A, Marchal JA, Prados J, Rodríguez-
Serrano F, et al. Nanomedicine: Application areas and development
prospects. Int J Mol Sci 2011;12:3303-21.
21. Liu C, Lv L, Guo W, Mo L, Huang Y, Li G, et al. Self-nanoemulsifying
drug delivery system of tetrandrine for improved bioavailability:
Physicochemical characterization and pharmacokinetic study. BioMed
Res Int 2018;2018:1-10.
22. Zhang L, Zhang L, Zhang M, Pang Y, Li Z, Zhao A, et al. Selfemulsifying
drug delivery system and the applications in herbal drugs.
Drug Deliv 2015;22:475-86.
23. Parmar K, Patel J, Sheth N. Self nano-emulsifying drug delivery system
for embelin: Design, characterization and in vitro studies. Asian J
Pharm Sci 2015;10:396-404.
24. Joshi RP, Negi G, Kumar A, Pawar YB, Munjal B, Bansal AK, et al.
SNEDDS curcumin formulation leads to enhanced protection from pain
and functional deficits associated with diabetic neuropathy: An insight
into its mechanism for neuroprotection. Nanomedicine 2013;9:776-85.
25. Kaur G, Chandel P, Harikumar SL. Formulation development of self
nanoemulsifying drug delivery system [Snedds] of celecoxib for
improvement of oral bioavailability. Pharmacophore 2013;4:120-33.
26. Chakraborty K, Shivakumar A, Ramachandran S. Nano-technology in
herbal medicines: A review. Int J Herb Med 2016;4:21-7.
Statistics
62 Views | 45 Downloads
Citatons
How to Cite
MUSTIKA, A., FATIMAH, N., & SARI, G. M. (2019). FORMULATION AND CHARACTERIZATIONS OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF EXTRACT PETIVERIA ALLIACEA (SINGAWALANG) LEAVES. International Journal of Applied Pharmaceutics, 11(5), 61-65. https://doi.org/10.22159/ijap.2019.v11s5.T0050
Section
Original Article(s)