PREPARATION OF ORAL CURCUMIN DELIVERY FROM 3D-NANO-CELLULOSE NETWORKS MATERIAL PRODUCED BY ACETOBACTER XYLINUM USING OPTIMIZATION TECHNIQUE
Keywords:Acetobacter xylinum, Characterization, Curcumin, Loading, Optimization, 3D-nano-cellulose networks material (3DCM)
Objective: To prepare oral curcumin delivery and optimize curcumin loading of 3D-nano-cellulose networks material (3DCM) by looking into the impact of process variables on the response utilizing response surface methodology (RSM) and Box-Behnken design.
Methods: Optimization of curcumin loading of 3DCM was conducted using RSM and Box-Behnken model. Impact of four independent variables, including, the concentration of curcumin (X1), temperature (X2), shaking speed (X3), and time of loading (X4), was studied on one dependent response, that is, an amount of loaded curcumin (Y). Characterization of optimized 3DCM including curcumin was examined by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) analysis .
Results: R2 value for Y was approximately 0.94. X1 possessed the biggest positive impact compared to X2, X3 and X4. Optimized conditions for curcumin loading of 3DCM were X1 at 3 mg/ml, X2 at 40 °C, X3 at 120 rpm and X4 at 120 min. SEM photograph of 3DCM surfaces were found including fibers creating a 3D network structure. FTIR spectra studies depicted that there was no interaction between curcumin and 3DCM.
Conclusion: The data obtained in this study thus suggest that curcumin loaded 3DCM was successfully fabricated to give a potential oral delivery system of curcumin.
Ullah H, Santo HA, Khan T. Applications of bacterial cellulose in food, cosmetics and drug delivery. Cellulose 2016;23:2291-314.
Moniri M, Moghaddam AB, Azizi S, Rahim RA, Ariff AB, Saad WZ, et al. Production and status of bacterial cellulose in biomedical engineering. Nanomaterials (Basel) 2017;7:1-26.
Amin MCIM, Abadi A, Ahmad N, Katas H, Jamal JA. Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties. Sains Malays 2012;41:561-8.
Huang L, Chen X, Nguyen TX, Tang H, Zhang L, Yang G. Nano-cellulose 3D-networks as controlled-release drug carriers. J Mater Chem B 2013;1:2976-84.
Ullah H, Badshah M, Makila E, Salonen J, Shahbazi MA, Santos HA, et al. Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery. Cellulose 2007;24:1445-54.
Badshah M, Ullah H, Khan SA, Park JK, Khan T. Preparation, characterization and in vitro evaluation of bacterial cellulose matrices for oral drug delivery. Cellulose 2017;24:5041-52.
Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006;78:2081-7.
Samal HB, Das IJ, Patra CN, Sreenivas SA. Design and in vitro evaluation of curcumin dental films for the treatment of periodontitis. Asian J Pharm 2017;11:579-87.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 2013;15:195-218.
Athira GK, Jyothi AN. Preparation and characterization of curcumin loaded cassava starch nanoparticles with improved cellular absorption. Int J Pharm Pharm Sci 2014;6:171-6.
Franklyne JS, Nadarajan AR, Ebenazer A, Tiwari N, Mukherjee A, Chandrasekaran N. Preparation and characterization of edible oil nanoemulsions for enhanced stability and oral delivery of curcumin. Int J Appl Pharm 2018;10:139-46.
Shelat P, Mandowara VK, Gupta DG, Patel S. Formulation of curcuminoid loaded solid lipid nanoparticles in order to improve oral bioavailability. Int J Pharm Pharm Sci 2015;7:278-82.
Hestrin S, Schramm M. Synthesis of cellulose by Acetobacter xylinum, 2. Preparation of freeze-dried cells capable of polymerizing glucose to cellulose. Biochem J 1954;58:345-52.
Bhattacharya S. Statistical interpretation and optimization of valsartan floating tablets using Box-Behnken design. Int J Appl Pharm 2019;11:44-53.
Kuswandi B, Jayus, Larasati TS, Abdullah A, Heng LY. Real-time monitoring of shrimp spoilage using on-package sticker sensor based on natural dye of curcumin. Food Anal Methods 2012;5:881-9.
Nguyen TX, Huang L, Liu L, Abdalla AME, Gauthier M, Yang G. Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride. J Mater Chem B 2014;2:7149-59.
Nguyen TX. Isolation of Acetobacter xylinum from kombucha and application of cellulose material produced by bacteria from some culture media for drug carrier. Int J Sci Res 2019;8:1044-9.