THERAPEUTIC EVALUATION OF CHEMICALLY SYNTHESIZED COPPER NANOPARTICLES AGAINST FULL-THICKNESS EXCISIONAL WOUND HEALING
CNPs and wound healing
Nano-formulation is an advanced therapeutic system emerging in the new era. A numerous investigation has been carried out to revisit the biomedical application of Copper. It has been reported as a promising metallic based therapeutic agent used against various pathological states. Conventionally, it has been revealed that copper has anti-bacterial, anti-inflammatory, cardio-protective, anti-diabetic potential. Conversely, limited research is available regarding the wound healing ability of copper nanoparticles (CNPs). The present study reports the synthesis of CNPs by single-step cementation method, and their physicochemical characterization, including particle size, zeta potential, elemental analysis, and electron microscopy. Furthermore, the synthesized nanoparticles were evaluated for antibacterial activity, along with their hemocompatibility. Formulation of CNPs showed a significant increase in anti-inflammatory cytokine levels, attributed to accelerated wound healing. Moreover, histological photomicrographs of wound skin samples confirm the reduction in inflammatory cytokines, increased level of collagen deposition and accelerated re-epithelization which endorse the acceleration of wound healing.
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