FLUCONAZOLE NANOGEL: FABRICATION AND IN VITRO EVALUATION FOR TOPICAL APPLICATION
Objective: The aim of this study is to develop and in-vitro evaluation of prepared fluconazole nanogel for seborrheic dermatitis
Methods: Fluconazole nanogel was formulated to act against seborrheic dermatitis. The fluconazole nanoparticles were prepared by a simplified evaporation method and evaluated for particle size, entrapment efficiency, and percent in-vitro drug release. The nanogel was also characterized based on parameters like particle size, percent entrapment efficiency, shape surface morphology, rheological properties, in vitro release, and release kinetics.
Results: The particle size was found to be in the range of 119.0 nm to 149.5 nm, with a cumulative percent drug release of 95 % up to 18 h. The formulation with particle size 149.50±0.5 with maximum was selected for loading to form nanogel.
Conclusion: The data obtained from physical properties and rheological properties of nanogel revealed that the formulation shows viscosity with the ability of spreadability and flow index. The release kinetics proves the formulation to be diffusion controlled, depending on the swelling index.
2. Del Rosso JQ. Adult seborrheic dermatitis: a status report on practical topical management. J Clin Aesthet Dermatol 2011;5:32–8.
3. Manríquez JJ, Uribe P. Seborrhoeic dermatitis. BMJ Clin Evid 2007;1:1713.
4. Mubarak Al, Hibah. Fluconazole Nano-Particles Loaded Gel for Improved Efficacy in Treatment of Oral Candidiasis. Int. J. Pharmacol 2019;3:436–40.
5. Abdellatif, Ahmed AH. et al. Hydrogel Containing PEG-Coated Fluconazole Nanoparticles with Enhanced Solubility and Antifungal Activity. J. Pharm. Innov 2018;2: 112-22.
6. Nagaich U, Gulati N, Chauhan S. Antioxidant and Antibacterial Potential of Silver Nanoparticles: Biogenic Synthesis Utilizing Apple Extract. Journal of Pharmaceutics 2016;8:209-18.
7. Garala K, Joshi P, Shah M, Ramkishan A, Patel J. Formulation and evaluation of periodontal in situ gel. Int J Pharm Investig. 2013;1:29–41.
8. Chauhan S, Gulati N & Nagaich U. Fabrication and evaluation of ultra deformable vesicles for atopic dermatitis as topical delivery. Int J Polym Mater 2019;5:266-77.
9. Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. J Control Release 2016;4:77–92.
10. Parhi R. Cross-Linked Hydrogel for Pharmaceutical Applications: A Review. Adv Pharm Bull 2017;4:515–30.
11. Bashir S, Teo YY, Naeem S, Ramesh S, Ramesh K. pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil. PLoS One 2017;7:e0179250.
12. Kumar A, Pandit V, Nagaich U. Therapeutic evaluation of chemically synthesized copper nanoparticles to promote full-thickness excisional wound healing. Int J App Pharm 2020;6:136-42.
13. Alipour S, Shirooee A, Ahmadi F. Porogen effects on aerosolization properties of fluconazole loaded plga large porous particles. Int J App Pharm 2020;4:258-63.
14. Berk T, Scheinfeld N. Seborrheic dermatitis. P T 2010;6:348-52.
15. Nickie D. Greer. Voriconazole: The Newest Triazole Antifungal Agent, Baylor University Medical Center Proceedings. 2003:2:241-8
16. Borda LJ, Wikramanayake TC. Seborrheic Dermatitis and Dandruff: A Comprehensive Review. J Clin Investig Dermatol 2015;2:10.13188/2373-1044.1000019
17. Savage DT, Hilt JZ, Dziubla TD. In Vitro Methods for Assessing Nanoparticle Toxicity. Methods Mol Biol 2019;1-29.
This work is licensed under a Creative Commons Attribution 4.0 International License.