FLUCONAZOLE NANOGEL: FABRICATION AND IN VITRO EVALUATION FOR TOPICAL APPLICATION
Keywords:Seborrheic dermatitis, Fluconazole, Nanogel, Topical application
Objective: The aim of this study is to develop and in vitro evaluation of prepared fluconazole nanogel for seborrheic dermatitis
Methods: Fluconazole nanogel was formulated to act against seborrheic dermatitis. The fluconazole nanoparticles were prepared by a simplified evaporation method and evaluated for particle size, entrapment efficiency, and percent in vitro drug release. The nanogel was also characterized based on parameters like particle size, percent entrapment efficiency, shape surface morphology, rheological properties, in vitro release R² = 0.9046, and release kinetics.
Results: The nanoparticle with a combination of Eudragit RS and Tween 80 showed the best result with particle size in the range of 119.0 nm to 149.5 nm, with a cumulative percent drug release of 95 % up to 18 h. The formulated nanogel with optimum concentration of HPMC authenticate with particle size 149.50±0.5 with maximum drug release (92.13±0.32) %.
Conclusion: Different percentages of polymers (ethyl-cellulose, eudragit, and tween 80) are used as variable components in the formulation of nanogel. The optimized batch showed good physical properties (flow index, spreadability, and viscosity) along with rapid drug release. Therefore, it can be concluded that nanogel containing fluconazole has potential application in topical delivery.
Manriquez JJ, Uribe P. Seborrhoeic dermatitis. BMJ Clin Evid 2007;1:1713.
El-Housiny S, Shams Eldeen MA, El-Attar YA. Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study. Drug Delivery 2018;1:78-90.
Del Rosso JQ. Adult seborrheic dermatitis: a status report on practical topical management. J Clin Aesthet Dermatol 2011;5:32–8.
Nickie D, Greer. Voriconazole: the newest triazole antifungal agent. Baylor University Medical Center Proceedings 2003:2:241-8.
Berk T, Scheinfeld N. Seborrheic dermatitis. P T 2010;6:348-52.
Borda LJ, Wikramanayake TC. Seborrheic dermatitis and dandruff: a comprehensive review. J Clin Investig Dermatol 2015;2:10.
Alipour S, Shirooee A, Ahmadi F. Porogen effects on aerosolization properties of fluconazole loaded plga large porous particles. Int J Appl Pharm 2020;4:258-63.
Mubarak Al, Hibah. Fluconazole nano-particles loaded gel for improved efficacy in treatment of oral candidiasis. Int J Pharmacol 2019;3:436–40.
Abdellatif, Ahmed AH. Hydrogel containing PEG-coated fluconazole nanoparticles with enhanced solubility and antifungal activity. J Pharm Innov 2018;2:112-22.
Garala K, Joshi P, Shah M, Ramkishan A, Patel J. Formulation and evaluation of periodontal in situ gel. Int J Pharm Investig 2013;1:29–41.
Nagaich U, Gulati N, Chauhan S. Antioxidant and antibacterial potential of silver nanoparticles: biogenic synthesis utilizing apple extract. J Pharm 2016;8:209-18.
Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. J Controlled Release 2016;4:77–92.
Bashir S, Teo YY, Naeem S, Ramesh S, Ramesh K. pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil. PLoS One 2017;7:e0179250.
Chauhan S, Gulati N, Nagaich U. Fabrication and evaluation of ultra deformable vesicles for atopic dermatitis as topical delivery. Int J Polym Mater 2019;5:266-77.
Parhi R. Cross-linked hydrogel for pharmaceutical applications: a review. Adv Pharm Bull 2017;4:515–30.
Kumar A, Pandit V, Nagaich U. Therapeutic evaluation of chemically synthesized copper nanoparticles to promote full-thickness excisional wound healing. Int J Appl Pharm 2020;6:136-42.
Savage DT, Hilt JZ, Dziubla TD. In vitro methods for assessing nanoparticle toxicity. Methods Mol Biol 2019;1894:1-29.