FLUCONAZOLE NANOGEL: FABRICATION AND IN VITRO EVALUATION FOR TOPICAL APPLICATION

  • DIVYA
  • INDERBIR SINGH
  • UPENDRA NAGAICH

Abstract

Objective: The aim of this study is to develop and in-vitro evaluation of prepared fluconazole nanogel for seborrheic dermatitis


Methods: Fluconazole nanogel was formulated to act against seborrheic dermatitis. The fluconazole nanoparticles were prepared by a simplified evaporation method and evaluated for particle size, entrapment efficiency, and percent in-vitro drug release. The nanogel was also characterized based on parameters like particle size, percent entrapment efficiency, shape surface morphology, rheological properties, in vitro release, and release kinetics.


Results: The particle size was found to be in the range of 119.0 nm to 149.5 nm, with a cumulative percent drug release of 95 % up to 18 h. The formulation with particle size 149.50±0.5 with maximum was selected for loading to form nanogel.


Conclusion: The data obtained from physical properties and rheological properties of nanogel revealed that the formulation shows viscosity with the ability of spreadability and flow index.  The release kinetics proves the formulation to be diffusion controlled, depending on the swelling index.

Keywords: Seborrheic Dermatitis, Fluconazole, Nanogel, Topical application

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DIVYA, SINGH, I., & NAGAICH, U. (2021). FLUCONAZOLE NANOGEL: FABRICATION AND IN VITRO EVALUATION FOR TOPICAL APPLICATION. International Journal of Applied Pharmaceutics, 13(4). https://doi.org/10.22159/ijap.2021v13i4.40531
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