FORMULATION OF GEL FROM GYNURA SEGETUM EXTRACT AND ITS ACTIVITY ON BURN WOUND HEALING
Objective : The aims of this study was to formulate gel from GS extract and evaluate its burn-healing activity.
Method : GS extract was formulated using carbomer and carboxymethylcellulose (CMC) as stabilizer with various concentration. Furthermore, the gel of GS extract were evaluated including organoleptic, pH and viscosity. A burn-healing evaluation was conducted by making a wound with a hot plate on male Wistar rats, and 600 mg of the gel was applied. Subsequently, the presence of erythema and width contraction of the burns were observed for 15 d.
Results : The result showed that the formulation containing 1 % of carbomer and 1.2 % of GS extract has the best physical stability. The gel also increased the rate of healing process with decreased burn wound contraction (5.67 mm after 15-days) and the erythema than the control (8.50 mm after 15-days).
Conclusion : This finding demonstrated that the gel of GS extract can significantly improve the burns wound healing process and may also be used for topical preparation.
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