ANTIPYRETIC ACTIVITY OF CENTELLA (CENTELLA ASIATICA (L.) URBAN) HERB IN VACCINE INDUCED MICE

Authors

  • NYI MEKAR SAPTARINI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, West Java, Indonesia 45363
  • ENDAH KARTIKAWATI Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Al Ghifari University, West Java, Indonesia 40293

DOI:

https://doi.org/10.22159/ijap.2021.v13s3.16

Keywords:

Centella, Infusion, DPT vaccine, Paracetamol

Abstract

Objective: This study aimed to determine the antipyretic activity of the infusion of centella (Centella asiatica (L.) Urban) herb, based on empirically usage of Indonesian people.

Methods: Antipyretic activity assay was conducted to Swiss-Webster mice, which induced by diphtheria-pertussis-tetanus (DPT) vaccine with paracetamol as positive control.

Results: Centella herb was contained tannins, flavonoids, monoterpenoids, sesquiterpenoids, triterpenoids, steroids, and saponins. The antipyretic activity of centella infusion has a ratio 1:44.6, compare to paracetamol.

Conclusion: Antipyretic activity of centella herbs was predicted due to its secondary metabolites.

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Published

10-03-2021

How to Cite

SAPTARINI, N. M., & KARTIKAWATI, E. (2021). ANTIPYRETIC ACTIVITY OF CENTELLA (CENTELLA ASIATICA (L.) URBAN) HERB IN VACCINE INDUCED MICE. International Journal of Applied Pharmaceutics, 13(3), 76–78. https://doi.org/10.22159/ijap.2021.v13s3.16

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