• HERNITA TAURUSTYA Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences University of Bengkulu, Bengkulu, Indonesia
  • SRI YUNITA Department of Physiology, Faculty of Medicine and Health Sciences University of Bengkulu, Bengkulu, Indonesia https://orcid.org/0000-0002-5980-7525
  • YSRAFIL YSRAFIL Department of Pharmacy, Health Polytechnic of Gorotalo, Gorontalo, Indonesia
  • NUKE PRATIWI Undergraduate of Medical Sciences, Faculty of Medicine and Health Sciences University of Bengkulu, Bengkulu, Indonesia
  • ANINDITA RAHMATIAH Undergraduate of Medical Sciences, Faculty of Medicine and Health Sciences University of Bengkulu, Bengkulu, Indonesia




Convalescent plasma, COVID-19, Effectivity, neutralizing antibody, SARS-CoV2, Therapy


Objective: Recently, convalescent plasma (CP) therapy has shown promising evidence in the treatment of several serious contagious diseases, including SARS-CoV, Influenza and Ebola. We conducted a systematic review to extract data about using CP treatment for COVID-19 patients and its effectivity.

Methods: The retrieval of studies was conducted according to Cochrane Collaboration and from electronic databases including PubMed, Medline, and others (medRxiv and BioRxiv). Searching of available evidence concerning CP treatment of COVID-19 patients was conducted in journal articles published between December 2019 and October 2020. The articles were further screened based on inclusion and exclusion criteria to identify the high quality studies for analysis.

Results: A total of 18 CP studies were included in this review. We found variance regarding the effectiveness of CP in the reduction of mortality rate, length of stay, and increased discharging rate. Several findings show CP therapy is effective in increasing viral negativity, neutralizing antibodies to recipients, does not cause harmful adverse reactions and in some cases can improve clinical symptoms. This therapy is presently considered effective for generating good clinical outcomes when given early in the course of the disease.

Conclusion: The effectiveness of CP in terms of mortality, length of stay, and increased discharging patients is still debatable. However, CP therapy is effective to increase the negativity of SARS-CoV-2 test, neutralizing antibody titer and is safe so it can be considered for COVID-19 patients. CP should not be given in the initial disease course but is recommended for the early disease course.


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How to Cite

TAURUSTYA, H., YUNITA, S., YSRAFIL, Y., PRATIWI, N., & RAHMATIAH, A. (2021). LESSONS AND NEW PERSPECTIVES: IS CONVALESCENT PLASMA THERAPY EFFECTIVE ON COVID-19 PATIENTS?. International Journal of Applied Pharmaceutics, 14(1). https://doi.org/10.22159/ijap.2022v14i1.42452



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