FORMULATION AND CHARACTERIZATION OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FRACTION OF N-HEXANE: ETHYL ACETATE FROM SESEWANUA LEAF (CLERODENDRUM FRAGRANS WILD.)

Authors

  • ZULFIAYU SAPIUN Department of Pharmacy, Health Polytechnic of Gorontalo, Indonesia https://orcid.org/0000-0003-2246-2778
  • ARLAN K. IMRAN Department of Pharmacy, Health Polytechnic of Gorontalo, Indonesia https://orcid.org/0000-0003-1729-3666
  • SISILIA TERESIA ROSMALA DEWI Department of Pharmacy, Health Polytechnic of Makassar, Indonesia
  • DHEA FADILA MASITA PADE Department of Pharmacy, Health Polytechnic of Gorontalo, Indonesia
  • WIDYAWATI IBRAHIM Department of Pharmacy, Health Polytechnic of Gorontalo, Indonesia
  • ROBERT TUNGADI Department of Pharmacy, State University of Gorontalo, Indonesia
  • WIDY SUSANTI ABDULKADIR Department of Pharmacy, State University of Gorontalo, Indonesia
  • YOS BANNE Department of Pharmacy, Health Polytechnic of Manado, Indonesia
  • YUSNITA RIFAI Department of Pharmacy, Hasanuddin University, Indonesia
  • SARTINI SARTINI Department of Pharmacy, Hasanuddin University, Indonesia
  • ANDI DIAN PERMANA Department of Pharmacy, Hasanuddin University, Indonesia
  • YUSNITA RIFAI Department of Pharmacy, Hasanuddin University, Indonesia
  • YSRAFIL YSRAFIL Faculty of Medicine, Universitas Palangka Raya, Palangka Raya, Indonesia https://orcid.org/0000-0002-5980-7525
  • NANGSIH SULASTRI SLAMET Center of Excellent for Cardiovascular and Endocrine, Health Polytechnic of Gorontalo, Indonesia https://orcid.org/0000-0002-7515-1175

DOI:

https://doi.org/10.22159/ijap.2023v15i2.46365

Keywords:

surfactant, co-surfactant, particle size, polydispersity index

Abstract

Objective: Sesewanua leaves contain alkaloid compounds as antioxidants, and its leaves can be used to formulate  SNEDDS dosage forms, which can effectively deliver the medicine.

This study intended to determine the variation of surfactant concentration (Tween 80) and cosurfactant (PEG 400) towards pH, viscosity, nano-emulsion duration and characterization using PSA method (particle size and polydispersity index).

Methods: This study employed quasi-experimental method and the independent variables in this study were variations in the concentration of surfactant (Tween 80) and cosurfactant (PEG 400), which consist of 3 formulas, such as SFS 1 (6:3), SFS 2 (7:2), and SFS 3 (8:1). The dependent variables in this study including pH, viscosity, nano-emulsion time, particle size and polydispersity index which utilized  One Way Anova Post Hoc LSD (p>0.05) and Tamhane (p<0.05) tests as the data analysis.

Results: The pH test SFS1-SFS3 has a pH value of 7.92, 8.30 and 8.35, followed by  Viscosity test SFS1-SFS3 which has a viscosity value of 1.00 cP, 1.38 cP and 2.91 cP.  Further, SFS1-SFS3 nano emulsified time test had nano emulsified time in gastric and intestinal fluids 35.18s & 43.96s, 43.54s & 47.13s and 44.00s & 50.29s. Characterization of SFS1-SFS3 particle size in gastric and intestinal fluids 23.9nm & 23.0nm, 18.5nm & 22.7nm and 19.1nm & 22.9nm, while characterization of SFS1-SFS3 polydispersity index in gastric and intestinal fluids were 0.433 & 0.348, 0.451 & 0.440 and 0.568 & 0.462.

Conclusion: The increase of variations in surfactant concentration and decreased cosurfactant significantly affected pH, viscosity, nano-emulsion time, and particle size of SFS preparations. However, the polydispersity index was not considerably affected.

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Published

22-12-2022

How to Cite

SAPIUN, Z., IMRAN, A. K., ROSMALA DEWI, S. T., MASITA PADE, D. F., IBRAHIM, W., TUNGADI, R., ABDULKADIR, W. S., BANNE, Y., RIFAI, Y., SARTINI, S., PERMANA, A. D., RIFAI, Y., YSRAFIL, Y., & SLAMET, N. S. (2022). FORMULATION AND CHARACTERIZATION OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FRACTION OF N-HEXANE: ETHYL ACETATE FROM SESEWANUA LEAF (CLERODENDRUM FRAGRANS WILD.). International Journal of Applied Pharmaceutics, 15(2). https://doi.org/10.22159/ijap.2023v15i2.46365

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