• IKE SUSANTI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy/Universitas Padjadjaran, Sumedang 45363, (West Java) Indonesia
  • HOLIS ABDUL HOLIK Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy/Universitas Padjadjaran, Sumedang 45363, (West Java) Indonesia



Adsorbent, Magnetic nanoparticle, Magnetic solid-phase extraction


This review aimed to inform about the magnetic nanoparticle functionalization and solid magnetic phase extraction application to separate analytes in various types of samples. The review was conducted by analyzing several articles published in 2010 until 2021 obtained through search engines, such as Science Direct, Google Scholar and PubMed, using the keyword “magnetic phase extraction” and “magnetic nanoparticle”. The magnetic nanoparticle can be functionalized with organic, inorganic, and metal-organic framework compounds to obtain good selectivity and extraction capability. The Magnetic Solid Phase Extraction (MSPE) can be applied to separate analytes in biological, food, environmental samples. The MSPE can be used in various biological, food, and environmental samples resulting in high enrichment factor value, good recovery, and the magnetic adsorbent has excellent reusability.


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How to Cite

SUSANTI, I., & HOLIK, H. A. (2021). REVIEW: APPLICATION OF MAGNETIC SOLID-PHASE EXTRACTION (MSPE) IN VARIOUS TYPES OF SAMPLES. International Journal of Applied Pharmaceutics, 13(4), 59–68.



Review Article(s)