LIPOPHILICITY PROFILING ON THE BASIC OF OECD GUIDELINE OF HARIDRA HYDROALCOHOLIC EXTRACT ON THE BASIS OF ITS MARKER COMPOUND CURCUMIN
Objective: The objective of this study was to calculate the lipophilicity (LOG P) of Haridra extracts on the basis of their main chemical compound curcumin.
Methods: As per the OECD guidelines for the testing of chemical adopted by the council on July 27, 1995, partition, and partition coefficient (n-octanol/ water): Shake flask method, this experiment is performed in this first extracts are prepared by raw herbal drugs (Haridra, coarse powder). Snyder classified solvents based on their interactions with three solutes determined by their gasâ€“liquid partition coefficients corrected for differences in solvent size, polarizability, and dispersion interactions.
Results: Haridra shows hydrophilicity and its marker compound shows LOG P.
Conclusion: Haridra is highly useful drugs its pharmacological activity is anti-inflammation, useful in the skin. However, where curcumin is more potent due to its lipophilic property. It is highly useful in various alignments.
N SJL. Dravyaguna Vigyan. In. Varanasi: Chaukhamba Orientalia; 2005. p. 513-514.
Mand JK, Soni GL, Gupta PP, Singh R. J Res Educ Ind Med 1991;10:1-7.
Ghosh A, Li P, Ghosh A, Wagner RF, Krill S, Joshi YM, Serajuddin AT. Effect of combined use of non-ionic surfactant on formation of oil-in-water micro emulsions. Int J Pharm 1993;31:116-20.
Mathur R, Sharma A, Dixit VP, Varma M.J Ethnopharmacol 1996;50:61-8.
Singh BN, Sharma PV. Herbalism, photochemistry and ethno pharmacology. J Res Ind Med 1971;5:223.
Wang NP, Wang ZF, Tootle S, Philip T, Zhao ZQ. Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction. Br J Pharmacol 2012;167(7):1550-62.
Al-gubury HY, Almaamory ES, Alsaady HH, Almurshidy GS. Photocatalytic degradation of aquatic rhodamine B solution using ultraviolet light and zinc oxide. Res J Pharm Biol Chem Sci 2015;6:929.
Ruwaida AR, Al-gubury HY, Aseel MA, Ayad FA. Photocatalytic degradation of reactive green dye by using zinc oxide. J Chem Pharm Sci 2016;9:1134-8.
Al-gubury HY. The effect of coupled titanium dioxide and cobalt oxide on photocatalytic degradation of malachite green. Int J Chem Tech Res 2016;9:227-35.
Stahl E, editor. Thin-Layer Chromatography. A Laboratory Handbook. 2nd ed. Berlin, Heidelberg: Springer; 1969.
Gasparic J, Kralove H. Chromatography on thin layers impregnated with organic stationary phases. Adv Chromatogr 1992;31:153-252.
OECD. Test Guideline 107, Decision of the Council C (81) 30 Final. Paris: OECD; 1981.
Hansch C, Leo AJ. Substituent Constants for Correlation Analysis in Chemistry and Biology. New York: John Wiley; 1979.
Renberg L, Sundstrom G, Sundh-Nygard K. Application of reverse-phase h.p.l.c. for the determination of partition coefficients. Chemosphere 1980;80:683.
Ellgehausen H, Dâ€™Hondt C, Fuerer R. Reversed-phase chromatography as a general method for determining octan-1-ol/water partition coefficients. Pestic Sci 1981;12:219.
McDuffie B. Chemosphere 1981, 10, 73-82. 2. Howard, PH, editor. Handbook of Fate and Exposure Data for Organic Chemicals II. Chelsea: Lewis Publishers; 1990.
Hammers WE, Meurs G J, De Ligny CL. Activity coefficients.interfacial tensions and retentionin reversed-phaseliquid chromatographyon lichrosorbrp-is with methanol-watermixtures. J Chromatographia 1982;247: 1-13.
Keihanian F, Saeidinia A, Bagheri RK, Johnston TP, Sahebkar A. Curcumin, haemostasis, thrombosis and coagulation; J Cell Physiol. DOI: 10.1002/jcp.26249.