A PROSPECTIVE STUDY OF DRUG UTILIZATION PATTERN OF ANTI-EPILEPTIC DRUGS AND THEIR ADVERSE EFFECTS IN A TERTIARY CARE HOSPITAL


Henry Daniel Raj T, Sylvia A., Chidambaranathan S., Nirmala P.

Abstract


Objective: Epilepsy or seizure disorder is a common neurologic disorder in the pediatric age group and occurs with a frequency of 4-6 cases per thousand children. Epilepsy, particularly childhood epilepsy, remains a challenge to treat. The management of epilepsy is primarily based on theuse of anti-epileptic drugs. Surgery and diet therapy are the other modes of treating childhood seizures. To get an insight into the utilization pattern of anti-epileptic drugs (AEDs) used in pediatric seizures.

Methods: This prospective, longitudinal study was conducted for a period of 8months in Paediatric Neurology Department of a tertiary care teaching hospital. The data collected from 50 children at the end of the study, were compiled in a specially designed data form and were analyzed.

Results: The distribution of paediatric seizures was found to be high in male children (62%) and in the age group of 2 to 5 y (46%). The majority of the children (70%) were diagnosed with Generalized Tonic-clonic seizures. Sodium valproate was the commonly prescribed AED in all forms of seizures followed by Carbamazepine (18%), Phenobarbitone (4%) and Phenytoin Sodium (4%). AEDs were mostly prescribed as monotherapy (82%). Adverse reactions noted during this study was minimal (12%).

Conclusion: Sodium valproate, a conventional AED still remains the commonly prescribed AED for all types of seizures in children aged 2 to 16 y and also was found to be effective and safe.

Keywords


Drug utilization study (DUS), Anti-Epileptic Drugs (AEDs), Adverse Reactions (AR), Seizure disorder

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About this article

Title

A PROSPECTIVE STUDY OF DRUG UTILIZATION PATTERN OF ANTI-EPILEPTIC DRUGS AND THEIR ADVERSE EFFECTS IN A TERTIARY CARE HOSPITAL

Keywords

Drug utilization study (DUS), Anti-Epileptic Drugs (AEDs), Adverse Reactions (AR), Seizure disorder

DOI

10.22159/ijcpr.2017v9i6.23427

Date

14-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 6 (Oct-Nov), 2017 Page: 42-45

Online ISSN

0975-7066

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14 Views | 5 Downloads

Authors & Affiliations

Henry Daniel Raj T
Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
India

Sylvia A.
Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

Chidambaranathan S.
Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

Nirmala P.
Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India


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