A PROSPECTIVE STUDY OF DRUG UTILIZATION PATTERN OF ANTI-EPILEPTIC DRUGS AND THEIR ADVERSE EFFECTS IN A TERTIARY CARE HOSPITAL

  • Henry Daniel Raj T Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
  • Sylvia A. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
  • Chidambaranathan S. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
  • Nirmala P. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

Abstract

Objective: Epilepsy or seizure disorder is a common neurologic disorder in the pediatric age group and occurs with a frequency of 4-6 cases per thousand children. Epilepsy, particularly childhood epilepsy, remains a challenge to treat. The management of epilepsy is primarily based on theuse of anti-epileptic drugs. Surgery and diet therapy are the other modes of treating childhood seizures. To get an insight into the utilization pattern of anti-epileptic drugs (AEDs) used in pediatric seizures.

Methods: This prospective, longitudinal study was conducted for a period of 8months in Paediatric Neurology Department of a tertiary care teaching hospital. The data collected from 50 children at the end of the study, were compiled in a specially designed data form and were analyzed.

Results: The distribution of paediatric seizures was found to be high in male children (62%) and in the age group of 2 to 5 y (46%). The majority of the children (70%) were diagnosed with Generalized Tonic-clonic seizures. Sodium valproate was the commonly prescribed AED in all forms of seizures followed by Carbamazepine (18%), Phenobarbitone (4%) and Phenytoin Sodium (4%). AEDs were mostly prescribed as monotherapy (82%). Adverse reactions noted during this study was minimal (12%).

Conclusion: Sodium valproate, a conventional AED still remains the commonly prescribed AED for all types of seizures in children aged 2 to 16 y and also was found to be effective and safe.
Keywords: Drug utilization study (DUS), Anti-Epileptic Drugs (AEDs), Adverse Reactions (AR), Seizure disorder

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Raj T, H. D., S. A., C. S., and N. P. “A PROSPECTIVE STUDY OF DRUG UTILIZATION PATTERN OF ANTI-EPILEPTIC DRUGS AND THEIR ADVERSE EFFECTS IN A TERTIARY CARE HOSPITAL”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 6, Nov. 2017, pp. 42-45, doi:10.22159/ijcpr.2017v9i6.23427.
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