COMPARATIVE ANALYSIS OF EFFICACY AND SAFETY OF DIACEREIN VERSUS S-ADENOSYL METHIONINE IN THE MANAGEMENT OF OSTEOARTHRITIS OF KNEE JOINT


Gayathri C. R., Vanitha Samuel, John William Felix, Nirmala P.

Abstract


Objective: Osteoarthritis (OA) the most common type of arthritis is a degenerative joint disease primarily affecting the articular cartilage and its surrounding tissue. Drugs like Diacerein and S-adenosyl methionine (SAMe) are used to remodel the cartilage and slow the progression of the disease, by acting through different mechanisms. Though there is documented evidence of the efficacy of both agents used individually in several clinical trials only a few studies report a comparison. To analyse the efficacy and safety of Diacerein Versus S-adenosyl methionine in the treatment of Osteoarthritis of knee joint.Methods: A prospective randomised interventional study was planned comparing diacerein with SAMe for 12 w in the management of OA of the knee. 40 patients in each group were randomly assigned to receive either diacerein 50 mg twice daily or S-adenosyl methionine 200 mg thrice daily for 12 w. Both groups received a short course of diclofenac 50 mg bd for one week, to tide over the acute symptoms.Results: Assessment of both drugs individually showed an equieffective potential in reducing osteoarthritis pain over a period of 12 w. But the comparison between the two groups showed a marginal improvement in pain relief from the 4th to 12th week of assessment in the diacerein group.Conclusion: Both the drugs for the treatment of OA, were shown to be effective in relieving pain but with a slower onset of action. Since no radiological changes were observed during the 12-week protocol, studies of longer duration are needed to evaluate the long-term effectiveness of these drugs.

Keywords


Osteoarthritis, Diacerein, S-adenosyl methionine, Diclofenac

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About this article

Title

COMPARATIVE ANALYSIS OF EFFICACY AND SAFETY OF DIACEREIN VERSUS S-ADENOSYL METHIONINE IN THE MANAGEMENT OF OSTEOARTHRITIS OF KNEE JOINT

Keywords

Osteoarthritis, Diacerein, S-adenosyl methionine, Diclofenac

DOI

10.22159/ijcpr.2017v9i6.23428

Date

14-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 6 (Oct-Nov), 2017 Page: 46-51

Online ISSN

0975-7066

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18 Views | 3 Downloads

Authors & Affiliations

Gayathri C. R.
Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

Vanitha Samuel
Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

John William Felix
Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

Nirmala P.
Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India


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