FAST DISSOLVING TABLET USING SOLID DISPERSION TECHNIQUE: A REVIEW
Keywords:Solid dispersion technique, Fast dissolving tablet
AbstractFast dissolving tablets are also called as mouth-dissolving tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quicker the absorption and onset of clinical effect. Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. Fast dissolving tablet containing solid dispersion was developed to improve the dissolution of drug and stability of solid dispersion. They are disintegrating and/or dissolve rapidly in the saliva without the need for water. Thus it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. The later part of the article focus on the progress in methods of manufacturing, evaluation and various latest technologies involved in the development of Fast dissolving tablets. Solid dispersion is basically a drugâ€“polymer two-component system; the drugâ€“polymer interaction is the determining factor in its design and performance. It also discusses about modern characterization technique to characterize solid dispersion. In this review, it is intended to discuss the recent advances related on the area of solid dispersion technology. Different methods are also been used for preparation of solid dispersions such as Melting method, Solvent method, Melting solvent method, Melt extrusion method, lyophilisation Technique, Melt Agglomeration Process, The Use Of Surfactant, Electro spinning and Super Critical Fluid Technology. The introduction of fast dissolving dosage forms has solved some of the problems encountered in administration of drugs to the pediatric and elderly patient, which constitutes a large proportion of the world's population. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bio availability of a range of poorly water-soluble drugs. The focus of one part of the review article is based on solid dispersion mainly advantages, disadvantages, types, the method of preparation, and characterization of the solid dispersion at laboratory and industrial level.
Hannan PA, Khan JA, Khan A, Safiullah S. Oral dispersible system: a new approach in drug delivery syste. Indian J Pharm Sci 2016;78:2-7.
Patel TS, Sengupta M. Fast dissolving tablet technology. World J Pharm Sci 2017;2:485-508.
Bhowmik D, Chiranjib B, Krishnakanth, Pankaj, Chandira RM. Fast dissolving tablet: an overview. J Chem Pharm Res 2016;1:163-77.
Siddiqui N, Garg G, Sharma PK. Fast dissolving tablets: preparation, characterization and evaluation: an overview. Int J Pharm Sci 2015;2:87-96.
Kumari S, Visht S, Sharma PK, Yadav RK. Fast dissolving drug delivery system: a review article. J Pharm Res 2016;3:1444-9.
Mohanachandran PS, Sindhumol PG, Kiran TS. Superdisintegrants: an overview. Int J Pharm Sci Rev Res 2015;6:105-9.
Deshmukh VN. Mouth dissolving drug delivery system: a review. Int J Pharm Tech Res 2016;4:412-21.
Leunar C, Dreessan J. Improving drug solubility for oral delivary using solid dispersion. Eur J Pharm Biopharm 2014;50:47-60.
Gupta DK, Bajpai M, Chatterjee DP. Fast mouth is dissolving disintegrating tablet and patient counselling points for FDDTSa review. Int J Res Dev Pharm Life Sci 2014;3:949-58.
Nautiyal U, Singh S, Singh R, Gopal, Kakar S. Fast dissolving tablets as a novel boon: a review. J Pharm Chem Biol Sci 2014;2:5-26.
Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res 2011;1:1-7.
Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharm Sci 2015;4:35-45.
Kumaresan C. Orally disintegrating tablet-mouth dissolving, sweet taste and target release profile. Pharmaceutical 2015;6:25-36.
Eun JK. Preparation of solid dispersion of felodipine using a solvent wetting method. Eur J Pharm Biopharm 2016;64:200-5.
Kazi PA, Gholve SB, Kazi SN. Review article solid dispersion: an evergreen method for solubility enhancement of poorly water soluble drugs. Int J Res Pharm Chem 2014;4:906-18.
Parkash V, Maan S, Deepika, Yadav SK, Hemlata, Jogpal V. Fast disintegrating tablets: opportunity in drug delivery system. J Adv Pharm Technol Res 2014;2:223-35.
Velmurugan S, Vinushitha S. Oral disintegrating tablets: an overview. Int J Chem Pharm Sci 2016;1:1-12.
Argade GD, Magar DD, Saudagar RB. Review article on solid dispersion as solubility enhancement technique for poorly water soluble drugs. J Adv Pharm Edu Res 2013;3:427-39.
Singh J, Walia M, Harikumar SL. Formulation and evaluation of fast dissolving tablets of rosuvastatin. J Drug Delivery Ther 2013;3:148-55.
Dixit AK, Singh RP, Singh Stuti. Formulation and evaluation of solid dispersion of amlodipine besylate. Int J Res Pharm Biomed Sci 2015;3:960-6.
Sameer Singh, Raviraj Singh Baghel, Lalit Yadav. A review on solid dispersion. Int J Pharm Life Sci 2016;2:1078-95.
Varun RJ, Venkateshwarlu L, Srikanth L. Combinational products: a regulatory review. Int J Pharm Sci Rev Res 2015;5:41-51.
Chauhan R, Virmani S, Suman P. Quantitative method development and validation of sulfasalazine in tablet dosage form by uv-spectroscopy. Int J Pharm Sci Rev Res 2015;2:120-9.
KV, Raj GB, Ravishanker D, Kumar CA. Preparation and evaluation of montelukast oral dispersible tablets by direct compression method. Int Res J Pharm 2014;7:315-8.
Yang D, Kulkarni R, Behme RJ, Kotiyan PN. Effect of the melt granulation technique on the dissolution characteristics of griseofulvin. Int J Pharm 2015;329:72-80.
Khan AB, Tripuraneni A. Fast dissolving tabletsâ€“a novel approach in drug delivery. Rguhs J Pharm Sci 2014;1:7-16.
Chowdary YA, Soumya M, Madhubabu M, Aparna K, Himabindu P. A review on fast dissolving drug delivery systems-A pioneering drug delivery technology. Bull Environ Pharmacol Life Sci 2015;1:8-20.
Abdulraheman ZS, Patel MR, Patel KR. A review on immediate release tablet. Int J Univers Pharm Bio Sci 2016;3:93-113.