• Puja Saha Noida Institute of Engineering and Technology
  • Sushma Verma Pharmacy Institute, Noida Institute of Engineering and Technology
  • Pratik Swarup Das Noida Institute of Engineering and Technology



Sublingual route, Patient compliance, Dysphagia, Sublingual technologies


Sublingual literally meaning is under the tongueâ€, refers to a method of administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. Sublingual route is a useful when rapid onset of action is desired with better patient compliance than orally ingested tablets. Drugs that are given sublingually reach directly in to the systemic circulation through the ventral surface of the tongue and floor of the mouth. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic firstâ€pass metabolic processes giving acceptable bioavailability. As nowadays most of the people need effective relief within a short period of time so sublingual is the most suitable form of administration. New sublingual technologies address many pharmaceutical and patient needs, ranging from enhanced lifeâ€cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients with dysphagia.


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Ishikawa T, Koizumi N, Mukai B. Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PHâ€Mâ€06) and spherical sugar granules. Chem Pharm Bull 2009;49:230â€2.

Price TM, Blauer KL, Hansen M, Stanczyk F, Lobo R, Bates GW. Singleâ€dose pharmacokinetics of sublingual versus oral administration of micronized 17 betaâ€estradiol. Obstet Gynecol 2007;89:340â€5.

KL Moore, AF Dalley, Anne MR. Agur. Eds. Clinically Oriented Anatomy. 6th ed. Lippincott Williams and Wilkins, Philadelphia, PA; 2009. p. 944.

CA Squier, PW Wertz. Structure and function of the oral mucosa and implications for drug delivery,†in oral mucosal drug delivery. MJ Tathbone. Ed. (Marcel Dekker, New York, NY; 2006. p. 1-26.

Kurosaki Y, Takatori T, Nishimura H, Nakayama T, Kimura T. Regional variation in oral mucosal drug absorption permeability and degree of keratinization in hamster oral cavity. Pharm Res 2011;8:1297â€301.

Narang N, Sharma J. Sublingual mucosa as a route for systemic drug delivery. Int J Pharm Pharm Sci 2010;3:18-22.

Richman MD, Fox D, Shangraw RF. Preparation and stability of glyceryl trinitrate sublingual tablets prepared by direct compression. J Pharm Sci 2015;54:447â€51.

Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: developments, technologies, tastemaking and clinical studies. Crit Rev Ther Drug Carrier Syst 2014;21:433â€76.

Katz M, Barr M. A study of sublingual absorption I. Several factors influencing the rate of adsorption. J Am Pharm Assoc Am Pharm Assoc (Baltim) 2015;44:419â€23.

Koland M, Sandeep VP, Charyulu NR. Fast dissolving sublingual films of ondansetron hydrochloride: effect of additives on in vitro drug release and mucosal permeation. J Young Pharm 2010;2:216-2.

Fung HL, Yap SK, Rhodes CT. Development of a stable sublingual nitroglycerine tablets. Formulation and evaluation of tablet containing povidone. J Pharm Sci 2006;65:558-60.

Nandita GD, Sudip KD. Development of mucoadhesive dosage forms of buprenorphine for sublingual drug delivery. Drug Delivery 2004;11:89-95.

Sindhu Abraham, Basavaraj BV, Bharath S, Deveswaran R, Sharon F, Madhavan V. Formulation and optimization of sublingual tablets of rabeprazole sodium. Int J Pharm Sci Res 2010;5:50-4.

Boer D. Drug absorption by sublingual and rectal routes. Br J Anaesthesia 2014;56:69â€82.

Alâ€Ghananeem AM, Malkawi AH, Crooks PA. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech 2016;7:23.

John DN, Fort S, Lewis MJ, Luscombe DK. Pharmacokinetics and pharmacodynamics of Verapamil following sublingual and oral administration to healthy volunteers. Br J Clin Pham 2012;33:623â€7.

Rameshwari S, Jeya AJ. Formulation and evaluation of nifedipine sublingual tablets. Asian J Pharm Clin Res 2009;2:44-8.

Nafee NA, Boraie NA, Ismail FA, Mortada IM. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharm 2013;53:199â€212.

Bottenbrg P, Cleymact R, dc Muynck C, Reymon JP, Coomans D, Michotte Y, et al. Development and testing of fluoride containing slow release tablets for oral use. J Pharm Pharmacol 2001;43:457â€64.

Peh KK, Wong CF. Polymeric films as vehicles for buccal delivery; swelling, mechanical, and bioadhesive properties. J Pharm Sci 2009;2:53â€61.

Yeola GS, Darandale S, Khire A, Vavia PR. Fabrication and statistical optimization of a polysaccharide-based sublingual film of buprenorphine hydrochloride for breakthrough pain management: in vitro and in vivo performance. Drug Delivery Translational Res 2014;4:116-25.

Sudarshan K Singh, Agham A Sameer. Development and characterization of sublingual tablet of Lisinopril. Asian Pacific J Trop Biomed 2012;11:236-369.

Haegeli L, Brunnerâ€La Rocca HP, Wenk M, Pfisterer M, Drewe J, Krahenbuhl S. Sublingual administration of furosemide: new application of an old drug. Br J Clin Pharmcol 2007;64:804â€9.

USP/NF. Physical tests: disintegration 22/17. ed. Rockville MD: United States Pharmacopoeial Convention Inc; 1990.

USP/NF. Official Monographs: Nitroglycerin Tablets. 22/17. ed. Rockville MD: United States Pharmacopoeial Convention Inc; 1990.

Patel MV, Prajapati BG, Patel MM. Effect of hydrophilic polymers on buccoadhesive Eudragit patches of propranolol hydrochloride using factorial design. AAPS PharmSciTech 2007;8:45.

Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian J Pharm Sci 2008;70:43â€8.



How to Cite

Saha, P., S. Verma, and P. S. Das. “SUBLINGUAL DRUG DELIVERY: AN INDICATION OF POTENTIAL ALTERNATIVE ROUTE”. International Journal of Current Pharmaceutical Research, vol. 9, no. 6, Nov. 2017, pp. 5-7, doi:10.22159/ijcpr.2017v9i6.23436.



Review Article(s)