DESIGN AND CHARACTERISATION OF TRANSDERMAL PATCHES OF PHENFORMIN HYDROCHLORIDE


Pratik Swarup Das, Puja Saha

Abstract


Objective: In present work was designed to develop suitable transdermal matrix patches of Phenformin hydrochloride using various hydrophilic (HPMC) and hydrophobic (EUDRAGID) polymers as matrix formers.

Methods: Transdermal patches containing Phenformin hydrochloride were prepared by the solvent casting evaporation technique.

Results: Revealed that prepared patches showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The in vitro release study revealed that F3 formulation showed maximum release in 24 h. Formulation F3 was subjected for accelerated stability studies. The F3 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR.

Conclusion: Thus conclusion can be made that stable transdermal patches of Phenformin hydrochloride has been developed. F1, F2, F3, F4 formulations showed highest cumulative percentage drug release of 98.13%, 95.50%, 98.65%, 97.21% were obtained during in vitro drug release studies after 24 h. The release of Phenformin hydrochloride appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F3 formulation was concluded as optimized formulation.

Keywords


Phenformin hydrochloride, Ethyl cellulose, Sodium alginate, Poly ethylene glycol

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About this article

Title

DESIGN AND CHARACTERISATION OF TRANSDERMAL PATCHES OF PHENFORMIN HYDROCHLORIDE

Keywords

Phenformin hydrochloride, Ethyl cellulose, Sodium alginate, Poly ethylene glycol

DOI

10.22159/ijcpr.2017v9i6.23437

Date

14-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 6 (Oct-Nov), 2017 Page: 90-93

Online ISSN

0975-7066

Statistics

25 Views | 9 Downloads

Authors & Affiliations

Pratik Swarup Das
Pharmacy Institute, Noida Institute of Engineering and Technology

Puja Saha
Pharmacy Institute, Noida Institute of Engineering and Technology


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