CHROMOLAENA ODORATA: AS NATURE’S WOUND HEALER
Keywords:Chromolaena odorata, Wound healing, Antioxidant, Weed
According to the world health organization, more than 80% of the world’s population relies on traditional medicine for their primary health needs. The use of herbal medicines represents a long history of human interactions with the environment. The study of wound-healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemical are involved in the healing process of the body, including antioxidants and cytokines. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via the various mechanism. Injury to the soft tissues is followed by wound healing, which consists of four stages: hemostasis, inflammation, proliferation and remodeling. Chromolaena odorata is a weed that is traditionally used for the treatment of various ailments in humans and animals. However, it exhibits anti-inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable health care, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future use for the treatment of wounds.
2. Anupkumar C, Sujitrambhade, Umesh KP. Chromolaenaodorata (l.): an overview. J Pharm Res 2011;4:573-6.
3. Ukwueze SE, Duru OM, Shorinwa OE. Evaluation of the cutaneous wound healing activity of solvent fractions of chromolaena odorata linn. Indo Am J Pharm Res 2013;67:2231-6876.
4. Debashisha P, Santoshkumar D, Gourikumar D. Qualitative phytochemical analysis and investigation of anthelmintic and wound healing potentials of various extracts of chromolaena odorata linn. collected from the locality of mohuda village, berhampur (south orissa). Int J Pharm Biol Sci 2010;1:56-67.
5. Mahadeva R, Muhammad A, Khamsahsuryatimohd D. Phytochemical screening, total flavonoid and phenolic content assays of various solvent extracts of tepal. Malaysian J Anal Sci 2016;20:1181–90.
6. Akomas SC, Ijiomas SN. Bleeding and clotting time effect of ethanolic extracts of Chromolaena odorata versus Ocimum gratissicum treated albino rats. J Med Sci 2014;2:9-13.
7. Anushika S, Wannee J. Wound healing property review of siam weed, chromolaenaodorata. Pharmacogn Rev 2017;11:35–8.
8. Rajasree PH, Jessen G, Gritta S, Gowda DV. Formulation, phytochemical screening and physicochemical evaluation of an antiseptic ointment containing azadiractaindica and chromolenaodorata. Int J Pharm Biol Sci 2015;5:114-8.
9. Henshaw UO, Emmanuel KM. Haemostatic property of chromolaena odorata leaf extracts: in vitro and in vivo evaluation in wistar rats. J Biol Res 2016;89:2-4.
10. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;336:1736–43.
11. Vanita K, Sana S. A pharmacognostic and Pharmacological review on Chromolaena odorata (siam weed). Asian J Pharm Clin Res 2018;11:9-15.
12. Igboh MN, Ikewuchi JC, Ikewuchi CC. Chemical profile of chromolaena odorata L. (King and Robinson) leaves. Pakistan J Nutr 2009;8:521-4.
13. Karodi R, Jadhav M, Rub R, Bafna A. Evaluation of the wound healing activity of a crude extract of Rubia cordifolia L. (Indian madder) in mice. Int J Appl Res Nat Prod 2003;2:12–8.