MICROWAVE ASSISTED SYNTHESIS OF TETRAHYDROPYRMIDINE AND IN SILICO SCREENING OF ANTIDIABETIC DRUG

  • GEJALAKSHMI S. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, DR. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai-77
  • HARIKRISHNAN N. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, DR. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai-77
  • THILLAI GOVINDARAJAN G. E. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, DR. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai-77
  • DIVYASRI A. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, DR. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai-77

Abstract

Objective: To detect the microwave-assisted synthesis of Tetrahydropyrimidine derivative and its molecular docking studies for Diabetes.


Methods: The Bignelli condensation method was used for Tetrahydropyrimidine derivative synthesis. The docking studies made in Argus Lab software.


Results: The Tetrahydropyrimidine is synthesized using the microwave. The Tetrahydropyrimidine derivative is found to be attack the insulin receptor, as it the tendency of binding with insulin receptor showed in Argus lab. Further, the good binding site of Tetrahydropyrimidine derivative with insulin receptor was predicted.


Conclusion: From the research work, The Tetrahydropyrimidine derivative shows its affinity to bind with the insulin receptor. The binding value is averagely 7 which indicates it can attraction with the receptor, so it can control Diabetic mellitus by altering insulin secretion in blood plasma.

Keywords: Tetrahydropyrimidine, Microwave-assisted synthesis, Molecular docking study, Antidiabetic activity

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S., G., H. N., T. G. G. E., and D. A. “MICROWAVE ASSISTED SYNTHESIS OF TETRAHYDROPYRMIDINE AND IN SILICO SCREENING OF ANTIDIABETIC DRUG”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 1, Jan. 2020, pp. 10-13, doi:10.22159/ijcpr.2020v12i1.36821.
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