A REVIEW ON RECENT ADVANCEMENT IN PULSATILE DRUG DELIVERY SYSTEMS

  • GAURAV THAKUR Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Jalandhar, India 144020
  • SHAHID UD DIN WANI Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Jalandhar, India 144020
  • SURYA PRAKASH GAUTAM Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Jalandhar, India 144020

Abstract

Delivery systems with a pulsatile-release method are particularly involved in designing medicines for which traditional managed drug-release systems with the continuous release are not suitable. This medication also has a high first-pass impact or special conditions for chrono-pharmacology. These medications also have a high first-pass or unique chronopharmacological effect. The pulsatile release profile is characterised by a duration of no release (lag time) followed by a fast and full release of the drug. Pulsatile drug delivery systems may be classified into site-specific systems in which the drug is released inside the gastrointestinal system (e. g. colon) or time-controlled devices wherein the drug is released after a well-defined time period. Site-regulated release is typically controlled by environmental factors, such as pH or enzymes found in the intestinal tract, whereas drug release from time-controlled processes is controlled mainly by the delivery system and, preferably, not by the environment. This review covers various single-and multiple-unit oral pulsatile drug-delivery systems with an emphasis on time-controlled drug-release systems.

Keywords: Circadian, Pulsatile, Drug delivery, Advancement

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How to Cite
THAKUR, G., S. U. D. WANI, and S. P. GAUTAM. “A REVIEW ON RECENT ADVANCEMENT IN PULSATILE DRUG DELIVERY SYSTEMS”. International Journal of Current Pharmaceutical Research, Vol. 13, no. 2, Mar. 2021, pp. 6-10, doi:10.22159/ijcpr.2021v13i2.41543.
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Review Article(s)