EXTRA VIRGIN OLIVE OIL EFFECT IN THE COMBINATION OF ALCOHOL AND BENZENE ON THE KIDNEY OF RATTUS NOVERGICUS
Keywords:Ethanol, Benzene, Extra virgin olive oil, Nephron.
Aim & Objectives: This study investigated the use of Extra virgin olive oil, which is said to possess anti-inflammatory components as an ameliorative substance for the induced inflammation.
Material and Methods: Forty-eight (48) female Wistar rats were used for this study. They were divided into eight (1 - 8) groups (n = 6); Control, Ethanol, Benzene, E+B, E+O, B+O, E+B+O with administration of 25% Ethanol, 200mg/kg/b.w Benzene, 2ml (O) EVOO in respect to the tagged grouping names. Animals were euthanized through cervical dislocation after the last day of administration and the liver were excised and part was fixed in formalin solution of 10 % for histological processing and the other part were homogenized for biochemical assay in phosphate buffer before centrifugation.
Result: Histological evidence creates an understanding of the nephrons in which benzene and ethanol manifests likewise the mitigated ability of extra virgin olive oil. The relative organ weight provides information on the extent of the damage on nephrons. Kidney test level is significantly expressed.
Conclusion: Ethanol and benzene in combination cause serious damage; also, they separately induce nephrons dysfunction. Extra virgin olive oil was shown to mitigate these nephrons damages.
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Copyright (c) 2021 Adetunji Opeyemi Adebola1; Adetunji Oluwaseyi Adegoke, Nwobi Joseph Chigbogu, Adetunji Iyabode Toyin, Nwobi Nnenna Linda, Ogunbiyi Babafemi Tosin
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