EXTRA VIRGIN OLIVE OIL EFFECT IN THE COMBINATION OF ALCOHOL AND BENZENE ON THE KIDNEY OF RATTUS NOVERGICUS

Authors

  • ADETUNJI OPEYEMI ADEBOLA Department of Anatomy, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ogun State, Nigeria.
  • ADETUNJI OLUWASEYI ADEGOKE Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ogun State, Nigeria.
  • NWOBI JOSEPH CHIGBOGU Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ogun State, Nigeria.
  • ADETUNJI IYABODE TOYIN Department of Microbiology, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
  • OGUNBIYI BABAFEMI TOSIN Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ogun State, Nigeria.
  • NWOBI NNENNA LINDA Department of Chemical Pathology, School of Basic Clinical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ogun State, Nigeria.

DOI:

https://doi.org/10.22159/ijms.2021.v9i6.43029

Keywords:

Ethanol, Benzene, Extra virgin olive oil, Nephron

Abstract

Objective: This study investigated the use of extra virgin olive oil (EVOO), which is said to possess anti-inflammatory components as an ameliorative substance for the induced inflammation.

Methods: Forty-eight female Wistar rats were used for this study. They were divided into eight (1–8) groups (n=6); Control, Ethanol, Benzene, E+B, E+O, B+O, E+B+O with the administration of 25% Ethanol, 200 mg/kg/b.w Benzene, 2 ml (O) EVOO in respect to the tagged grouping names. Animals were euthanized through cervical dislocation after the last day of administration and the liver was excised and part was fixed in formalin solution of 10% for histological processing and the other part was homogenized for biochemical assay in phosphate buffer before centrifugation.

Results: Histological evidence creates an understanding of the nephrons in which benzene and ethanol manifest likewise the mitigated ability of EVOO. The relative organ weight provides information on the extent of the damage on nephrons. The kidney test level is significantly expressed.

Conclusion: Ethanol and benzene in combination cause serious damage; also, they separately induce nephrons dysfunction. EVOO was shown to mitigate these nephrons damages.

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Published

24-09-2021

How to Cite

OPEYEMI ADEBOLA, A., ADEGOKE, A. O., CHIGBOGU, N. J., TOYIN, A. I., TOSIN, O. B., & LINDA, N. N. (2021). EXTRA VIRGIN OLIVE OIL EFFECT IN THE COMBINATION OF ALCOHOL AND BENZENE ON THE KIDNEY OF RATTUS NOVERGICUS. Innovare Journal of Medical Sciences, 9(6), 19–22. https://doi.org/10.22159/ijms.2021.v9i6.43029

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