TREATMENT OF EXTRA-VIRGIN OLIVE OIL ON ETHANOL- AND BENZENE-INDUCED ACINAR CELLS DAMAGE IN ADULT WISTAR RATS

Authors

  • ADETUNJI OPEYEMI ADEBOLA Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
  • ADERUPOKO IDAYAT TOMILOLA Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
  • ADETUNJI OLUWASEYI ADEGOKE Department of Biochemistry, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
  • OGUNBIYI BABAFEMI TOSIN Department of Biochemistry, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
  • ADETUNJI IYABODE TOYIN Department of Pure and Applied Biology, Ladoke Akintola University, Ogbomoso, Oyo State, Nigeria.
  • NWOBI NNENNA LINDA Department of Chemical Pathology, School of Basic Clinical Sciences, Babcock University, Ogun State, Nigeria.
  • OGUNBIYI OLUBUNMI ESTHER Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
  • NWOBI JOSEPH CHIGBOGU Department of Biochemistry, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.a
  • BEJIDE AYODELE ROLAND Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.

DOI:

https://doi.org/10.22159/ijms.2022.v10i2.44088

Keywords:

Ethanol, Benzene, Extra Virgin-Olive Oil, Acinar Cells

Abstract

Objective: The study is focused on the effect ethanol and benzene on the acinar cells and extra- virgin olive oil (EVOO) as an ameliorative agent.

Methods: Forty-eight Wistar rats were divided into eight groups of six animals per group: (1) Control group (a placebo of water), (2) EVOO, (3) 25% ethanol, (4) 200 mg/kg benzene, (5) 25% ethanol+200 mg/kg benzene (EB), (6) 25% ethanol+EVOO (EO), (7) 200 mg/kg benzene+EVOO (BO), and (8) 25% ethanol+200 mg/kg benzene+EVOO (EBO). The ethanol, benzene, and EVOO were administered orally.

Results: All the treatment groups lost body weight except Groups 1 and 2. The histology of the pancreas showed significant (p≤0.05) damage to the acinar cells of groups exposed to 25% ethanol, 200 mg/kg benzene, and EB when compared to the control, EVOO, EO, BO, and EBO. The enzymatic activities of amylase and lipase evaluated showed significant (p≤0.05) decrease in EO and BO as compared to 25% ethanol, 200 mg/kg benzene, and EB-treated groups.

Conclusion: There was an elevated glucose concentration in 25% ethanol and EBO as compared to control and EVOO has anti-inflammatory potential across the ameliorated groups.

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Published

21-03-2022

How to Cite

ADEBOLA, A. O., TOMILOLA, A. I., ADEGOKE, A. O., TOSIN, O. B., TOYIN, A. I., LINDA, N. N., ESTHER, O. O., CHIGBOGU, N. J., & ROLAND, B. A. (2022). TREATMENT OF EXTRA-VIRGIN OLIVE OIL ON ETHANOL- AND BENZENE-INDUCED ACINAR CELLS DAMAGE IN ADULT WISTAR RATS. Innovare Journal of Medical Sciences, 10(2), 11–15. https://doi.org/10.22159/ijms.2022.v10i2.44088

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