ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF ORMOCARPUM SENNOIDES

Authors

  • S. Srividya Department of Biochemistry, Sathyabama University Dental College and Hospital, Rajiv Gandhi Salai, Old Mahabalipuram Road, Chennai-600119, Tamilnadu, India
  • G. Sridevi

Keywords:

Anti-inflammatory activity, Anti-arthritic activity, Ormocarpum sennoides, Rheumatoid arthritis

Abstract

Objective: The study focuses on evaluating the anti-inflammatory and anti-arthritic activity of ethanolic extract of Ormocarpum sennoides (Os), a herb belonging to the family fabaceae. Both in vitro and in vivo methods were employed to study the anti-inflammatory activity of Os extract.

Methods: The in vitro analysis of Os extract was performed by HRBC membrane stabilization and protein denaturation methods. The in vivo analysis was done by Formalin-induced paw edema and acetic acid induced writhing test using wistar male albino rats as an animal model.

Results: The in vitro analysis revealed the inhibition of hemolysis and protein denaturation in a dose-dependent manner in concentrations ranging from 50-500 µg/ml. The in vivo study showed that Os extract reduced the number of paw lickings and abdominal writhing significantly at dosage concentrations of 200 mg/kg body weight and 300 mg/kg body weight compared with standard diclofenac sodium (p<0.05).

Conclusion: These results support the application of Os extract in ailing arthritis and treatment of painful inflammatory conditions.

Keywords: Anti-inflammatory activity, Anti-arthritic activity, Ormocarpum sennoides, Rheumatoid arthritis

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Published

01-05-2016

How to Cite

Srividya, S., and G. Sridevi. “ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF ORMOCARPUM SENNOIDES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 5, May 2016, pp. 117-21, https://journals.innovareacademics.in/index.php/ijpps/article/view/10855.

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