EFFECTIVE MANAGEMENT OF HEMOLYTIC COMPLICATIONS BY TRADITIONALLY PREPARED KÄ€NTAM FORMULATIONS
Keywords:Nil, Hemolysis, Anti-hemolytic, Nil, Nil, Herbo-metallic Siddha drug
Objective: KÄntam based formulations are unique herbo-metallic preparations, used in Siddha system of medicine (Indian traditional medicine) for managing various haematological complications. Their therapeutic doses were also well established in Siddha literature. In this work an attempt was made to understand the comparative effect of three different kÄntam formulations in the management of hemolytic complications.
Methods: Hemolysis was induced in Wistar rats by intraperitoneal injection of acetylphenylhydrazine. Three different kÄntam formulations (KÄntac centÅ«ram1 (K1), KÄntac centÅ«ram2 (K2) and KÄntap parÌ±pam (K3) were administered with proper controls at their therapeutic doses (20.0 mg/day) for a period of 20 d. Cage side observations, hematological, biochemical and histopathological analysis were performed to understand the effect of the formulations.
Results: Cage-side observations revealed that only K1 is effective in curing oral ulcers formed during hemolysis. Haematological analysis revealed the effect of K1 and K3 in regulating reticulocyte maturation and effect of K1, K2 and K3 in the removal of extracellular haemoglobin. Histopathological analysis revealed the effect of K1 in regulating stress erythropoiesis and effect of K1, K2 and K3 in regulating kupffer cells in the liver. Overall, the kÄntam formulations demonstrate an appreciable relevance (in managing hemolytic conditions) within the contemporary pharmacological parlance.
Conclusion: Our study demonstrated the effective role of KÄntam formulations in the treatment of hemolytic complications by promoting reticulocyte maturation, removing extracellular haemoglobin, regulating stress erythropoiesis in the spleen, regulating kupffer cells in the liver and preventing oral ulcers. However, all the three formulations did not show all the activities and differ in efficacy profile.
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