EVALUTION OF ANALGESIC ACTIVITY OF LEAF EXTRACTS OF PERGULARIA DAEMIA [FORSK] IN EXPERIMENTAL ANIMALS
Objective: Pergularia daemia [Forsk] has been used from long time in traditional medicine. The main objective of this work is to evaluate analgesic activity of leaf of Pergularia daemia [Forsk]
Methods: Analgesic activity of petroleum ether and methanol extract of leaf of Pergularia daemia [Forsk] was evaluated by using Eddyâ€™s hot plate and tail immersion method.
Results: Preliminary Phytochemical investigation of Petroleum ether extract of leaf of Pergularia daemia [Forsk] shows presence of steroids, terpenoids, sterols while methanolic extract of leaf of Pergularia daemia [Forsk] shows presence of alkaloids, glycosides, flavonoids, tannins and phenolic component. The petroleum ether extract [300 mg/kg] shows delayed action in paw licking as well as in jumping whereas in the tail immersion method there was delayed time taken for flicking of tail out of water was recorded.
Conclusion: The methanol extract was found to be more potent than petroleum ether extract. The result indicate that the petroleum ether and methanol extract contain such Phytochemical constituents which are responsible for analgesic activity.
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